Laxatives as a Risk Factor for Iatrogenic Falls in Elderly Subjects: Myth or Reality?
Background: The multifactorial nature of falls is well known, and several studies on falls in the elderly have reported that laxatives can be a risk factor, but without attempting to discuss possible mechanisms to explain this role. Objective: We aimed to isolate studies in which the risk factors fo...
| Publicado en: | Drugs & Aging Vol. 27; no. 11; pp. 895 - 902 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105005480&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105005480 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1170229X C5B jtl: Drugs & Aging issn: 1170229X maglogo: N pubinfo: dt: 2010 vid: 27 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105005480 57802456 10.2165/11584280-000000000-00000 NLM20964463 105005480 ppf: 895 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Laxatives as a Risk Factor for Iatrogenic Falls in Elderly Subjects: Myth or Reality? aug: au: Bloch F Thibaud M Dugué B Brèque C Rigaud A Kemoun G affil: Department of Gerontology, Assistance Publique-Hôpitaux de Paris, Hôpital Broca, Paris, France.University of Poitiers, Laboratory of Exercise-Induced Physiological Adaptations, Poitiers, France. sug: subj: Accidental Falls Etiology Cathartics Adverse Effects Human Aged Medline Cross Sectional Studies Retrospective Design Meta Analysis Aged: 65+ years ab: Background: The multifactorial nature of falls is well known, and several studies on falls in the elderly have reported that laxatives can be a risk factor, but without attempting to discuss possible mechanisms to explain this role. Objective: We aimed to isolate studies in which the risk factors for falls in the elderly related to laxatives have been evaluated and to carry out a meta-analysis combining the results of all identified good-quality studies. Methods: Systematic literature review using the keywords `accidental fall/ numerical data' and `risk factors'. This was followed by a manual search for articles cited in the previously identified publications. Articles were analysed if they had study populations aged ≥60 years, reported on falls occurring in everyday life, were observational or interventional studies that identified laxatives as a risk factor for falls, and were written in French or English. Articles of this type that were considered to be of good quality were included in the meta-analysis. Results: 3747 indexed articles published between 1981 and 2007 were identified. Of these, seven articles met all inclusion criteria and were analysed. The odds ratio (95% CI) for the association between use of laxatives and fall occurrence in subjects participating in the good-quality trials (n=4) included in the meta-analysis was 2.03 (1 .52, 2.72). This result was statistically homogeneous (percentage of the total variation across studies due to heterogeneity [I²] = 0). Conclusions: Elderly subjects treated with laxatives were twice as likely to fall compared with non-laxative users. The causal relationship was probably not directly attached to a side effect of the substance used, but rather a reflection of other pathologies (e.g. older age, confinement to bed, concomitant Parkinson's disease) that may themselves cause falls. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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