Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions.
Cryptococcal immune reconstitution inflammatory syndrome (IRIS) may present as a clinical worsening or new presentation of cryptococcal disease after initiation of antiretroviral therapy (ART), and is thought to be caused by recovery of cryptococcus-specific immune responses. We have reviewed report...
| Publicado en: | Lancet Infectious Diseases Vol. 10; no. 11; pp. 791 - 803 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Nov2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105018014&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105018014 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14733099 KIL jtl: Lancet Infectious Diseases issn: 14733099 maglogo: N pubinfo: dt: Nov2010 vid: 10 iid: 11 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 105018014 NLM21029993 2010850496 10.1016/S1473-3099(10)70170-5 NLM21029993 PMC3026057 105018014 ppf: 791 ppct: 12 formats: tig: atl: Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions. aug: au: Haddow LJ Colebunders R Meintjes G Lawn SD Elliott JH Manabe YC Bohjanen PR Sungkanuparph S Easterbrook PJ French MA Boulware DR Haddow, Lewis J Colebunders, Robert Meintjes, Graeme Lawn, Stephen D Elliott, Julian H Manabe, Yukari C Bohjanen, Paul R Sungkanuparph, Somnuek Easterbrook, Philippa J affil: Division of Immunology, Infection and Inflammatory Disease, King's College London, London, UK sug: subj: Antiviral Agents Administration and Dosage Antiviral Agents Adverse Effects Cryptococcosis Diagnosis Cryptococcus HIV Infections Complications Anti-HIV Agents Immune Reconstitution Inflammatory Syndrome Diagnosis Cryptococcosis Microbiology Cryptococcosis Pathology Cryptococcus Immunology HIV Infections HIV-1 Immune Reconstitution Inflammatory Syndrome Microbiology Immune Reconstitution Inflammatory Syndrome Pathology ab: Cryptococcal immune reconstitution inflammatory syndrome (IRIS) may present as a clinical worsening or new presentation of cryptococcal disease after initiation of antiretroviral therapy (ART), and is thought to be caused by recovery of cryptococcus-specific immune responses. We have reviewed reports of cryptococcal IRIS and have developed a consensus case definition specifically for paradoxical crytopcoccal IRIS in patients with HIV-1 and known cryptococcal disease before ART, and a separate definition for incident cryptococcosis developed during ART (termed ART-associated cryptococcosis), for which a proportion of cases are likely to be unmasking cryptococcal IRIS. These structured case definitions are intended to aid design of future clinical, epidemiological, and immunopathological studies of cryptococcal IRIS, to standardise diagnostic criteria, and to facilitate comparisons between studies. As for definitions of tuberculosis-associated IRIS, definitions for cryptococcal IRIS should be regarded as preliminary until further insights into the immunopathology of IRIS permit their refinement. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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