Comparison of whole liver and small region-of-interest measurements of MRI liver R2* in children with iron overload.
Background: Measurement of liver MRI T2* and R2* is emerging as a reliable alternative to liver biopsy for the quantitation of liver iron content. A systematic investigation of the influence of the region-of-interest size and placement has not been conducted.Objective: To compare small and whole liv...
| Publicado en: | Pediatric Radiology Vol. 40; no. 8; pp. 1360 - 1368 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Springer Nature
Aug2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105043556&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105043556 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Aug2010 vid: 40 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105043556 NLM20333511 2010702036 10.1007/s00247-010-1596-8 NLM20333511 PMC3164974 105043556 ppf: 1360 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Comparison of whole liver and small region-of-interest measurements of MRI liver R2* in children with iron overload. aug: au: McCarville MB Hillenbrand CM Loeffler RB Smeltzer MP Song R Li CS Hankins JS McCarville, M Beth Hillenbrand, Claudia M Loeffler, Ralf B Smeltzer, Matthew P Song, Ruitan Li, Chin-Shang Hankins, Jane S affil: Department of Radiological Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 210, Memphis, TN 38105, USA sug: subj: Anemia, Sickle Cell Radiography Magnetic Resonance Imaging Iron Overload Pathology Liver Radiography Adolescence Adult Child Human Liver Pathology Male Observer Bias Young Adult Clinical Trials Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Male ab: Background: Measurement of liver MRI T2* and R2* is emerging as a reliable alternative to liver biopsy for the quantitation of liver iron content. A systematic investigation of the influence of the region-of-interest size and placement has not been conducted.Objective: To compare small and whole liver region-of-interest (ROI) MRI R2* values to each other and to biopsy liver iron content in patients with iron overload.Materials and Methods: Forty-one iron-overloaded patients, ages 7-35 years, underwent biopsy for liver iron content quantitation and MRI for liver R2* measurement within 30 days. Three reviewers independently used small and whole liver ROIs to measure R2*. Inter-reviewer agreement was assessed with the intra-class correlation coefficient (ICC). Associations between R2* and liver iron content were investigated using Spearman's rank-order correlation and Monte Carlo estimated exact P values.Results: Biopsy liver iron content and small and whole liver ROI R2* measurements were strongly associated for all reviewers (all P < 0.0001). Although inter-reviewer agreement was excellent for both ROI methods (ICC = 0.98-0.99), the small ROI technique more frequently led to inter-reviewer differences larger than 75 Hz, slightly higher R2* values, larger standard errors and greater range in values.Conclusion: Small and whole liver ROI techniques are strongly associated with biopsy liver iron content. We found slightly greater inter-reviewer variability in R2* values using the small ROI technique. Because such variability could adversely impact patient management when R2* values are near a threshold of iron chelation therapy, we recommend using a whole liver ROI. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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