Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection.
Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treate...
| Publicado en: | Journal of Infectious Diseases Vol. 202; no. 4; pp. 633 - 638 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
2010 Aug 15
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105053619&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105053619 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00221899 1YU jtl: Journal of Infectious Diseases issn: 00221899 maglogo: N pubinfo: dt: 2010 Aug 15 vid: 202 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105053619 105053619 NLM20594103 2010713708 10.1086/654813 NLM20594103 PMC2904428 105053619 ppf: 633 ppct: 5 formats: tig: atl: Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection. aug: au: Bryan RA Jiang Z Howell RC Morgenstern A Bruchertseifer F Casadevall A Dadachova E Bryan, Ruth A Jiang, Zewei Howell, Robertha C Morgenstern, Alfred Bruchertseifer, Frank Casadevall, Arturo Dadachova, Ekaterina affil: Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA sug: subj: Antifungal Agents Therapeutic Use Cryptococcosis Drug Therapy Cryptococcosis Therapy Cryptococcus Radioimmunotherapy Methods Amphotericin B Therapeutic Use Animals Antibodies Therapeutic Use Metals Therapeutic Use Brain Microbiology Colony Count, Microbial Cryptococcosis Microbiology Models, Biological Female Lung Microbiology Mice Radioisotopes Therapeutic Use Treatment Outcomes Female ab: Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with (213)Bi-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. (213)Bi-18B7 treatment almost completely eliminated colony-forming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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