Iron and folic acid supplements and reduced early neonatal deaths in Indonesia.
Objective To examine the relationship between antenatal care, iron and folic acid supplementation and tetanus toxoid vaccination during pregnancy in Indonesia and the risk of early neonatal death (death in days 0-6 of life). Methods We analysed pooled data on neonatal survival in singleton infants b...
| Publicado en: | Bulletin of the World Health Organization Vol. 88; no. 7; pp. 500 - 509 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
World Health Organization
Jul2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105056905&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105056905 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00429686 BUW jtl: Bulletin of the World Health Organization issn: 00429686 maglogo: N pubinfo: dt: Jul2010 vid: 88 iid: 7 pid: 437 pub: World Health Organization artinfo: ui: 105056905 2010717005 10.2471/BLT.09.065813 NLM20616969 PMC2897981 105056905 ppf: 500 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Iron and folic acid supplements and reduced early neonatal deaths in Indonesia. aug: au: Titaley CR Dibley MJ Roberts CL Hall J Agho K affil: Sydney School of Public Health, Edward Ford Building (A27), University of Sydney, NSW 2006, Australia; citaley@health.usyd.edu.au sug: subj: Folic Acid Administration and Dosage Infant Mortality Trends Iron Compounds Administration and Dosage Tetanus Toxoid Administration and Dosage Confidence Intervals Cox Proportional Hazards Model Data Analysis Software Data Analysis, Statistical Descriptive Statistics Female Funding Source Human Indonesia Infant, Newborn Multiple Logistic Regression Obstetric Care Pregnancy Infant, Newborn: birth-1 month Female ab: Objective To examine the relationship between antenatal care, iron and folic acid supplementation and tetanus toxoid vaccination during pregnancy in Indonesia and the risk of early neonatal death (death in days 0-6 of life). Methods We analysed pooled data on neonatal survival in singleton infants born in the 5 years before each of the Indonesian demographic and health surveys of 1994, 1997 and 2002-2003. Only the most recently born infant of each mother was included. Multivariate Cox proportional hazards models were used to identify factors linked to early neonatal death. Findings Of the 40 576 infants included, 442 experienced early neonatal death. After adjustment, the risk of early neonatal death was significantly reduced for infants of mothers who received either any form of antenatal care (hazard ratio, HR: 0.48; 95% confidence interval, CI: 0.31-0.73), any quantity of iron and folic acid (HR: 0.53; 95% CI: 0.36-0.77) or >= 2 tetanus toxoid injections (HR: 0.66; 95% CI: 0.48-0.92). When we analysed different combinations of these measures, iron and folic acid supplementation provided the main protective effect: early neonatal deaths were still significantly reduced among infants whose mothers received iron and folic acid supplements but no other form of antenatal care (HR: 0.10; 95% CI: 0.01-0.67), or the supplements but < 2 tetanus toxoid injections (HR: 0.46; 95% CI: 0.29-0.73). Subsequent analysis showed that 20% of early neonatal deaths in Indonesia could be attributed to a lack of iron and folic acid supplementation during pregnancy. Conclusion Iron and folic acid supplementation during pregnancy in Indonesia significantly reduced the risk of early neonatal death and could also do so in other low- and middle-income countries. © World Health Organization 2010. All rights reserved. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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