The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat.
Cognitive impairment and Alzheimer's disease are linked with intake of a Western diet, characterized by high levels of saturated fats and simple carbohydrates. In rats, these dietary components have been shown to disrupt hippocampal-dependent learning and memory processes, particularly those involvi...
| Publicado en: | Journal of Alzheimer's Disease Vol. 21; no. 1; pp. 207 - 220 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Sage Publications Inc.
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105063361&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105063361 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872877 FLR jtl: Journal of Alzheimer's Disease issn: 13872877 maglogo: N pubinfo: dt: 2010 vid: 21 iid: 1 pid: 20732 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 105063361 NLM20413889 2010725170 10.3233/JAD-2010-091414 NLM20413889 PMC4975946 105063361 ppf: 207 ppct: 13 formats: tig: atl: The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat. aug: au: Kanoski SE Zhang Y Zheng W Davidson TL Kanoski, Scott E Zhang, Yanshu Zheng, Wei Davidson, Terry L affil: Department of Psychological Sciences, Purdue University, West Lafayette, IN 19104-6241, USA sug: subj: Blood-Brain Barrier Cognition Disorders Etiology Cognition Disorders Dietary Fats Adverse Effects Hippocampus Metabolism Animals Behavior, Animal Body Weight Learning Models, Biological Motivation Genes Physiology Male Membrane Proteins Membrane Proteins Metabolism Rats Cell Membrane Metabolism Time Factors Male ab: Cognitive impairment and Alzheimer's disease are linked with intake of a Western diet, characterized by high levels of saturated fats and simple carbohydrates. In rats, these dietary components have been shown to disrupt hippocampal-dependent learning and memory processes, particularly those involving spatial memory. Using a rat model, the present research assessed the degree to which consumption of a high-energy (HE) diet, similar to those found in modern Western cultures, produces a selective impairment in hippocampal function as opposed to a more global cognitive disruption. Learning and memory performance was examined following 90-day consumption of an HE-diet in three nonspatial discrimination learning problems that differed with respect to their dependence on the integrity of the hippocampus. The results showed that consumption of the HE-diet impaired performance in a hippocampal-dependent feature negative discrimination problem relative to chow-fed controls, whereas performance was spared on two discrimination problems that do not rely on the hippocampus. To explore the mechanism whereby consuming HE-diets impairs cognitive function, we investigated the effect of HE-diets on the integrity of the blood-brain barrier (BBB). We found that HE-diet consumption produced a decrease in mRNA expression of tight junction proteins, particularly Claudin-5 and -12, in the choroid plexus and the BBB. Consequently, an increased blood-to-brain permeability of sodium fluorescein was observed in the hippocampus, but not in the striatum and prefrontal cortex following HE-diet access. These results indicate that hippocampal function may be particularly vulnerable to disruption by HE-diets, and this disruption may be related to impaired BBB integrity. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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