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Medicine-Based Evidence: Reverse Translational Ear Research Recommendations.

Presented here is a first-person account of the evolution of the practice of surgical neurootology to that of medical neurootology shaped mainly by results of treatment directed at underlying otosclerosis-like lesions of the otic capsule and metabolic factors. With new technologies and rapidly evolv...

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Published in:International Tinnitus Journal Vol. 15; no. 2; pp. 139 - 149
Main Author: Brookler KH
Format: Journal Article
Published: Martha Entenmann Tinnitus Research Center, Inc. 2009
Online Access:View this record in EBSCOhost
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      dt: 2009
      vid: 15
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      pub: Martha Entenmann Tinnitus Research Center, Inc.
      place: Brooklyn, New York
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        atl: Medicine-Based Evidence: Reverse Translational Ear Research Recommendations.
      aug:
        au: Brookler KH
        affil: Lenox Hill Hospital, New York, New York, USA
      sug:
        subj:
          Diphosphonates Therapeutic Use
          Medical Practice, Evidence-Based
          Hearing Loss, Sensorineural Therapy
          Labyrinth Diseases Physiopathology
          Labyrinth Diseases Therapy
          Meniere's Disease Physiopathology
          Meniere's Disease Therapy
          Migraine Physiopathology
          Migraine Therapy
          Otosclerosis Physiopathology
          Otosclerosis Therapy
          Tinnitus Physiopathology
          Tinnitus Therapy
          Animals
          Blood Glucose Metabolism
          Carbonic Anhydrase Inhibitors Therapeutic Use
          Carbonic Anhydrases Physiology
          Diabetes Mellitus, Type 2 Physiopathology
          Diabetes Mellitus, Type 2 Therapy
          Hair Cells Drug Effects
          Hair Cells Physiology
          Hearing Loss, Sensorineural Physiopathology
          Insulin Resistance
          Mice
          Macrophages Drug Effects
          Macrophages Physiology
          Receptors, Cell Surface Physiology
          Tumor Necrosis Factor Physiology
      ab: Presented here is a first-person account of the evolution of the practice of surgical neurootology to that of medical neurootology shaped mainly by results of treatment directed at underlying otosclerosis-like lesions of the otic capsule and metabolic factors. With new technologies and rapidly evolving concepts, the changing treatment algorithms did not remain constant to provide the usual evidence-based outcome analyses. However, the majority of the patients presenting with neurootological symptoms had undergone previous medical or surgical treatment before undergoing the medical management herein described. The underlying ongoing basic science findings over this period were linked to the clinical observations. On the basis of the more effective results of treating neurootological disorders, recommendations are made for future areas of investigation-mostly basic science-into developing an investigative foundation for future effective management of patients with a variety of neurootological disorders.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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