Downregulation of angiogenin transcript levels and inhibition of colonic carcinoma by Gum Arabic (Acacia senegal).
Gum Arabic (GA), a nutrient from dried exudate of Acacia senegal, is widely used as emulsifier and stabilizer. It stimulates sodium and water absorption in diarrhea. This study explored the effects of GA in colonic tissue. Mice were treated with GA (10% wt/vol) in drinking water and gene array was p...
| Publicado en: | Nutrition & Cancer Vol. 62; no. 6; pp. 802 - 811 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Aug/Sep2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105064013&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105064013 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Aug/Sep2010 vid: 62 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 105064013 2010726076 10.1080/01635581003605920 NLM20661830 105064013 ppf: 802 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Downregulation of angiogenin transcript levels and inhibition of colonic carcinoma by Gum Arabic (Acacia senegal). aug: au: Nasir O Wang K Föller M Bhandaru M Sandulache D Artunc F Ackermann TF Ebrahim A Palmada M Klingel K Saeed AM Lang F affil: University of Tuebingen, Tuebingen, Germany sug: subj: Colonic Neoplasms Prevention and Control Peptides Physiology Plants, Medicinal Therapeutic Use Analysis of Variance Animal Studies Antigens Blotting, Western Methods Colonic Neoplasms Physiopathology Colonic Neoplasms Therapy Descriptive Statistics Diarrhea Therapy Interleukins Mice Neoplasms Neovascularization, Physiologic Nutrition Oncogenes T-Tests ab: Gum Arabic (GA), a nutrient from dried exudate of Acacia senegal, is widely used as emulsifier and stabilizer. It stimulates sodium and water absorption in diarrhea. This study explored the effects of GA in colonic tissue. Mice were treated with GA (10% wt/vol) in drinking water and gene array was performed. As GA modified several tumor-relevant genes, chemical cancerogenesis (intraperitoneal injection of 20 mg/kg 1,2-dimethylhydrazine followed by 3 cycles of 3% dextrane sodium sulphate in drinking water) was induced with or without GA treatment. Within 4 days, GA treatment decreased the colonic transcript levels of the angiogenetic factors angiogenin 1, angiogenin 3, and angiogenin 4 by 78 ± 18%, 88 ± 15%, and 92 ± 13%, respectively (n = 5 each), and of further genes including CD38 antigen, aquaporin4, interleukin18, vav-3-oncogene, [gamma]+-amino acid transporter, sulfatase1, ubiquitinD, and chemokine ligand5. According to Western blotting, GA treatment similarly decreased angiogenin protein expression, and according to immunohistochemistry, it decreased ss-catenin expression. Chemical cancerogenesis resulted in multiple colonic tumors within 12 wk. GA treatment (10% wt/wt) in drinking water significantly decreased the number of tumors by 70%. The observations disclose a powerful anticarcinogenic effect of GA. The nutrient could thus be used for the prophylaxis against colon carcinoma particularly in individuals at enhanced risk. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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