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Comparative study of Nigella sativa and triple therapy in eradication of Helicobacter pylori in patients with non-ulcer dyspepsia.

Background/Aim: A large number of diseases are ascribed to Helicobacter pylori (H. pylori), particularly chronic active gastritis, peptic ulcer disease and gastric cancer. Successful treatment of H. pylori infection with antimicrobial agents can lead to regression of H. pylori-associated disorders....

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Published in:Saudi Journal of Gastroenterology Vol. 16; no. 3; pp. 207 - 215
Main Authors: Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, Randhawa MA
Format: clinical trial research tables/charts Journal Article
Published: Wolters Kluwer India Pvt Ltd Jul2010
Online Access:View this record in EBSCOhost
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        13193767
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      jtl: Saudi Journal of Gastroenterology
      issn: 13193767
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    pubinfo:
      dt: Jul2010
      vid: 16
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      pub: Wolters Kluwer India Pvt Ltd
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        10.4103/1319-3767.65201
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        105068180
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        atl: Comparative study of Nigella sativa and triple therapy in eradication of Helicobacter pylori in patients with non-ulcer dyspepsia.
      aug:
        au:
          Salem EM
          Yar T
          Bamosa AO
          Al-Quorain A
          Yasawy MI
          Alsulaiman RM
          Randhawa MA
        affil: Department of Physiology, College of Medicine, King Faisal University, Dammam, Saudi Arabia
      sug:
        subj:
          Amoxicillin Therapeutic Use
          Clarithromycin Therapeutic Use
          Dyspepsia Etiology
          Helicobacter Infections Drug Therapy
          Helicobacter Pylori
          Omeprazole Therapeutic Use
          Adult
          Alternative Therapies
          Analysis of Variance
          Chi Square Test
          Clinical Trials
          Confidence Intervals
          Data Analysis Software
          Equipment and Supplies
          Female
          Funding Source
          Helicobacter Infections Complications
          Helicobacter Infections Diagnosis
          Human
          Male
          Metronidazole Therapeutic Use
          Middle Age
          Patient History Taking
          Physical Examination
          Questionnaires
          Random Assignment
          Saudi Arabia
          Urease
          Wilcoxon Rank Sum Test
          Yates' Continuity Correction
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Female
          Male
      ab: Background/Aim: A large number of diseases are ascribed to Helicobacter pylori (H. pylori), particularly chronic active gastritis, peptic ulcer disease and gastric cancer. Successful treatment of H. pylori infection with antimicrobial agents can lead to regression of H. pylori-associated disorders. Antibiotic resistance against H. pylori is increasing, and it is necessary to find new effective agents. Nigella sativa seed (NS), a commonly used herb, possesses in vitro anti-helicobacter activity. The present study was undertaken to evaluate the efficacy of NS in eradication of H. pylori infection in non-ulcer dyspeptic patients. Materials and Methods: The study was conducted on 88 adult patients attending King Fahd Hospital of the University, Al-Khobar, Saudi Arabia, from 2007 to 2008, with dyspeptic symptoms and found positive for H. pylori infection by histopathology and urease test. Patients were randomly assigned to four groups, receiving i) triple therapy (TT) comprising of clarithromycin, amoxicillin, omeprazole [n= 23], ii) 1 g NS + 40 mg omeprazole (OM) [n= 21], iii) 2 g NS + OM [n= 21] or iv) 3 g NS + OM [n= 23]. Negative H. pylori stool antigen test four weeks after end of treatment was considered as eradication. Results: H. pylori eradication was 82.6, 47.6, 66.7 and 47.8% with TT, 1 g NS, 2 g NS and 3 g NS, respectively. Eradication rates with 2 g NS and TT were statistically not different from each other, whereas H. pylori eradication with other doses was significantly less than that with TT (P < 0.05). Dyspepsia symptoms improved in all groups to a similar extent. Conclusions: N. sativa seeds possess clinically useful anti-H. pylori activity, comparable to triple therapy. Further clinical studies combining N. sativa with antibiotics are suggested.
      pubtype: Academic Journal
      doctype:
        clinical trial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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