Endocytosis and recycling of tight junction proteins in inflammation.
A critical function of the epithelial lining is to form a barrier that separates luminal contents from the underlying interstitium. This barrier function is primarily regulated by the apical junctional complex (AJC) consisting of tight junctions (TJs) and adherens junctions (AJs) and is compromised...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 484987 - 484988 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105082000&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105082000 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2010 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105082000 2010748336 NLM20011071 PMC2789582 105082000 ppf: 484987 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Endocytosis and recycling of tight junction proteins in inflammation. aug: au: Utech M Mennigen R Bruewer M affil: Department of General and Visceral Surgery, University Hospital Muenster, 48149 Muenster, Germany. sug: subj: Endocytosis Physiology Inflammation Metabolism Membrane Proteins Metabolism Cell Membrane Metabolism Animals Intestinal Mucosa Intestinal Mucosa Metabolism ab: A critical function of the epithelial lining is to form a barrier that separates luminal contents from the underlying interstitium. This barrier function is primarily regulated by the apical junctional complex (AJC) consisting of tight junctions (TJs) and adherens junctions (AJs) and is compromised under inflammatory conditions. In intestinal epithelial cells, proinflammatory cytokines, for example, interferon-gamma (IFN-gamma), induce internalization of TJ proteins by endocytosis. Endocytosed TJ proteins are passed into early and recycling endosomes, suggesting the involvement of recycling of internalized TJ proteins. This review summarizes mechanisms by which TJ proteins under inflammatory conditions are internalized in intestinal epithelial cells and point out comparable mechanism in nonintestinal epithelial cells. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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