Which metabolic pathways generate and characterize the flux space? A comparison among elementary modes, extreme pathways and minimal generators.
Important efforts are being done to systematically identify the relevant pathways in a metabolic network. Unsurprisingly, there is not a unique set of network-based pathways to be tagged as relevant, and at least four related concepts have been proposed: extreme currents, elementary modes, extreme p...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 13p - 14 |
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| Autores principales: | , |
| Formato: | equations & formulas glossary review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105082174&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105082174 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2010 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105082174 2010748529 10.1155/2010/753904 NLM20467567 PMC2868190 105082174 ppf: 13p ppct: 1 formats: fmt: @attributes: type: P tig: atl: Which metabolic pathways generate and characterize the flux space? A comparison among elementary modes, extreme pathways and minimal generators. aug: au: Llaneras F Picó J affil: Instituto de Automática e Informática Industrial, Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain. kikollan@gmail.com sug: subj: Mathematics Metabolism Signal Transduction Mathematics Methods ab: Important efforts are being done to systematically identify the relevant pathways in a metabolic network. Unsurprisingly, there is not a unique set of network-based pathways to be tagged as relevant, and at least four related concepts have been proposed: extreme currents, elementary modes, extreme pathways, and minimal generators. Basically, there are two properties that these sets of pathways can hold: they can generate the flux space--if every feasible flux distribution can be represented as a nonnegative combination of flux through them--or they can comprise all the nondecomposable pathways in the network. The four concepts fulfill the first property, but only the elementary modes fulfill the second one. This subtle difference has been a source of errors and misunderstandings. This paper attempts to clarify the intricate relationship between the network-based pathways performing a comparison among them. pubtype: Academic Journal doctype: equations & formulas glossary review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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