Induction of specific CD8+ T cells against intracellular bacteria by CD8+ T-cell-oriented immunization approaches.
For protection against intracellular bacteria such as Mycobacterium tuberculosis and Listeria monocytogenes, the cellular arm of adaptive immunity is necessary. A variety of immunization methods have been evaluated and are reported to induce specific CD8(+) T cells against intracellular bacterial in...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 11p - 12 |
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| Autores principales: | , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105082193&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105082193 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2010 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105082193 105082193 2010748548 NLM20508818 PMC2875770 105082193 ppf: 11p ppct: 1 formats: fmt: @attributes: type: P tig: atl: Induction of specific CD8+ T cells against intracellular bacteria by CD8+ T-cell-oriented immunization approaches. aug: au: Nagata T Koide Y affil: Department of Health Science, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan. sug: subj: Antigens Bacteria Immunization T Lymphocytes Dendritic Cells DNA Listeria Mycobacterium Tuberculosis Peptides Retroviruses Salmonella Shigella Vaccines ab: For protection against intracellular bacteria such as Mycobacterium tuberculosis and Listeria monocytogenes, the cellular arm of adaptive immunity is necessary. A variety of immunization methods have been evaluated and are reported to induce specific CD8(+) T cells against intracellular bacterial infection. Modified BCG vaccines have been examined to enhance CD8(+) T-cell responses. Naked DNA vaccination is a promising strategy to induce CD8(+) T cells. In addition to this strategy, live attenuated intracellular bacteria such as Shigella, Salmonella, and Listeria have been utilized as carriers of DNA vaccines in animal models. Vaccination with dendritic cells pulsed with antigenic peptides or the cells introduced antigen genes by virus vectors such as retroviruses is also a powerful strategy. Furthermore, vaccination with recombinant lentivirus has been attempted to induce specific CD8(+) T cells. Combinations of these strategies (prime-boost immunization) have been studied for the efficient induction of intracellular bacteria-specific CD8(+) T cells. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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