Comparative pathogenesis and systems biology for biodefense virus vaccine development.
Developing vaccines to biothreat agents presents a number of challenges for discovery, preclinical development, and licensure. The need for high containment to work with live agents limits the amount and types of research that can be done using complete pathogens, and small markets reduce potential...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 11p - 12 |
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| Autores principales: | , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105082231&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105082231 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2010 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105082231 2010748586 10.1155/2010/236528 NLM20617142 PMC2896660 105082231 ppf: 11p ppct: 1 formats: fmt: @attributes: type: P tig: atl: Comparative pathogenesis and systems biology for biodefense virus vaccine development. aug: au: Bowick GC Barrett AD affil: Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, and Institute of Human Infections & Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA. gabowick@utmb.edu sug: subj: Biology Vaccines Virus Diseases Etiology Virus Diseases Pathology Immunity Learning ab: Developing vaccines to biothreat agents presents a number of challenges for discovery, preclinical development, and licensure. The need for high containment to work with live agents limits the amount and types of research that can be done using complete pathogens, and small markets reduce potential returns for industry. However, a number of tools, from comparative pathogenesis of viral strains at the molecular level to novel computational approaches, are being used to understand the basis of viral attenuation and characterize protective immune responses. As the amount of basic molecular knowledge grows, we will be able to take advantage of these tools not only to rationally attenuate virus strains for candidate vaccines, but also to assess immunogenicity and safety in silico. This review discusses how a basic understanding of pathogenesis, allied with systems biology and machine learning methods, can impact biodefense vaccinology. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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