Optimal fluxes, reaction replaceability, and response to enzymopathies in the human red blood cell.
Characterizing the capabilities, key dependencies, and response to perturbations of genome-scale metabolic networks is a basic problem with important applications. A key question concerns the identification of the potentially most harmful reaction knockouts. The integration of combinatorial methods...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 10p - 11 |
|---|---|
| Autores principales: | , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2010
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105082315&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105082315 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2010 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105082315 2010748670 10.1155/2010/415148 NLM20706609 PMC2914339 105082315 ppf: 10p ppct: 1 formats: fmt: @attributes: type: P tig: atl: Optimal fluxes, reaction replaceability, and response to enzymopathies in the human red blood cell. aug: au: De Martino A Granata D Marinari E Martelli C Van Kerrebroeck V affil: CNR Institute for Physico-Chemical Processes (IPCF), Rome Sapienza Unit, Roma, Italy. sug: subj: Enzymes Erythrocytes Metabolism Funding Source Human ab: Characterizing the capabilities, key dependencies, and response to perturbations of genome-scale metabolic networks is a basic problem with important applications. A key question concerns the identification of the potentially most harmful reaction knockouts. The integration of combinatorial methods with sampling techniques to explore the space of viable flux states may provide crucial insights on this issue. We assess the replaceability of every metabolic conversion in the human red blood cell by enumerating the alternative paths from substrate to product, obtaining a complete map of he potential damage of single enzymopathies. Sampling the space of optimal steady state fluxes in the healthy and in the mutated cell reveals both correlations and complementarity between topologic and dynamical aspects. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|