Speech motor program maintenance, but not switching, is enhanced by left-hemispheric deep brain stimulation in Parkinson's disease.
Speech reaction time (SRT) was measured in a response priming protocol in 12 participants with Parkinson's disease (PD) and hypokinetic dysarthria 'on' and 'off' left-hemispheric deep brain stimulation (DBS). Speech preparation was measured during speech motor programming in two randomly ordered spe...
| Publicado en: | International Journal of Speech-Language Pathology Vol. 12; no. 5; pp. 385 - 399 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105085683&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105085683 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17549507 8NBH jtl: International Journal of Speech-Language Pathology issn: 17549507 maglogo: Y pubinfo: dt: Oct2010 vid: 12 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 105085683 2010758871 10.3109/17549507.2010.491870 NLM20586527 105085683 ppf: 385 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Speech motor program maintenance, but not switching, is enhanced by left-hemispheric deep brain stimulation in Parkinson's disease. aug: au: Jones HN Kendall DL Okun MS Wu SS Velozo C Fernandez HH Spencer KA Rosenbek JC affil: Duke University, Durham, NC, USA sug: subj: Deep Brain Stimulation Left Brain Hemisphere Parkinson Disease Speech Disorders Treatment Outcomes Aged Brain Physiology Cognition Comparative Studies Cues Descriptive Statistics Dysarthria, Hypokinetic Experimental Studies Female Human Male Middle Age Motor Skills Random Assignment Reaction Time Speech Intelligibility Wilcoxon Rank Sum Test Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Speech reaction time (SRT) was measured in a response priming protocol in 12 participants with Parkinson's disease (PD) and hypokinetic dysarthria 'on' and 'off' left-hemispheric deep brain stimulation (DBS). Speech preparation was measured during speech motor programming in two randomly ordered speech conditions: speech maintenance and switching. Double blind testing was completed in participants with DBS of globus pallidus pars interna (GPi) (n=5) or subthalamic nucleus (STN) (n=7). SRT was significantly faster in the maintenance vs switch task, regardless of DBS state. SRT was faster in the speech maintenance task 'on' stimulation, while there was no difference in speech switching 'on' and ' off' DBS. These data suggest that left-hemispheric DBS may have differential effects on aspects of speech preparation in PD. It is hypothesized that speech maintenance improvements may result from DBS-induced cortical enhancements, while the lack of difference in switching may be related to inhibition deficits mediated by the right-hemisphere. Alternatively, DBS may have little influence on the higher level motor processes (i.e., motor planning) which it is believed the switch task engaged to a greater extent than the maintenance task. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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