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Hydroxyurea-induced foot ulcer in a case of essential thrombocythaemia.

Objective: To illustrate the association between hydroxyurea and the development of ulcers. Method: A case study is presented, in which histological changes, mean corpuscular volume (MCV) and transcutaneous oxygen tension (TcPO2) were all measured and analysed, both during hydroxyurea treatment and...

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Published in:Journal of Wound Care Vol. 19; no. 8; pp. 361 - 365
Main Authors: Tsuchiya S, Ichioka S, Sekiya N
Format: case study equations & formulas pictorial tables/charts Journal Article
Published: Mark Allen Holdings Limited Aug2010
Online Access:View this record in EBSCOhost
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        09690700
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      dt: Aug2010
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      pub: Mark Allen Holdings Limited
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        atl: Hydroxyurea-induced foot ulcer in a case of essential thrombocythaemia.
      aug:
        au:
          Tsuchiya S
          Ichioka S
          Sekiya N
        affil: Department of Plastic and Reconstructive Surgery, Saitama Medical University, Japan. Email: sunaot2006@yahoo.co.jp
      sug:
        subj:
          Hydroxyurea Adverse Effects
          Foot Ulcer Chemically Induced
          Wound Healing
          Erythrocyte Indices
          Neovascularization, Physiologic
          Hydroxyurea Pharmacodynamics
          Aged
          Female
          Wound Care
          Foot Ulcer Pathology
          Aged: 65+ years
          Female
      ab: Objective: To illustrate the association between hydroxyurea and the development of ulcers. Method: A case study is presented, in which histological changes, mean corpuscular volume (MCV) and transcutaneous oxygen tension (TcPO2) were all measured and analysed, both during hydroxyurea treatment and following it's discontinuation. Results: Two months following the cessation of hydroxyurea therapy, the patient's ulcer had healed completely. Biopsy specimens taken before and after its discontinuation showed a considerable improvement in vascularity, with a capillary density 6.28 times higher after discontinuation of the drug. TcPO2 was just 8mmHg at the first measurement, and this increased to 65mmHg at the second. Conclusion: These findings suggest deficient neovascularisation and circulation during hydroxyurea treatment. Changes in MCV also appeared to have an effect on the progress of wound healing, which supports the hypothesis that macroerythrocytosis may be involved in the development of these rare ulcers, via impairment of the microcirculatory rheology. Conflict of interest: None.
      pubtype: Academic Journal
      doctype:
        case study
        equations & formulas
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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