The synthesis of puerarin derivatives and their protective effect on the myocardial ischemia and reperfusion injury.
Puerarin is a naturally occurring isoflavone and is frequently used for the treatment of cardiovascular symptoms in China. By the structural modification of the puerarin molecule at different positions, seven new puerarin derivatives were obtained, and their cardioprotective activities (in vitro and...
| Publicado en: | Journal of Asian Natural Products Research Vol. 12; no. 10; pp. 843 - 851 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105113534&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105113534 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10286020 J40 jtl: Journal of Asian Natural Products Research issn: 10286020 maglogo: Y pubinfo: dt: Oct2010 vid: 12 iid: 10 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 105113534 54302730 10.1080/10286020.2010.505563 105113534 ppf: 843 ppct: 8 formats: tig: atl: The synthesis of puerarin derivatives and their protective effect on the myocardial ischemia and reperfusion injury. aug: au: Feng Z Wang Y Guo Z Chu F Sun P affil: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China sug: subj: Isoflavones Pharmacodynamics Isoflavones Analysis Myocardial Reperfusion Injury Drug Therapy Descriptive Statistics Animal Studies Models, Biological Molecular Structure China Drugs, Chinese Herbal Free Radical Scavengers Rats Quantitative Studies Myocardial Reperfusion Injury Physiopathology Myocardial Ischemia Physiopathology ab: Puerarin is a naturally occurring isoflavone and is frequently used for the treatment of cardiovascular symptoms in China. By the structural modification of the puerarin molecule at different positions, seven new puerarin derivatives were obtained, and their cardioprotective activities (in vitro and in vivo) were respectively evaluated. The finding that the activities of 3 and 8 markedly exceeded puerarin suggested that the acylated modification of phenolic hydroxyl at C-7 in the puerarin molecule may improve the cardioprotective activity, which will be an important reference for further structural optimization. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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