Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial.
Objective: To investigate the methylphenidate (MPH) response rate among childhood survivors of acute lymphoblastic leukemia (ALL) and brain tumors (BTs) and to identify predictors of positive MPH response.Methods: Cancer survivors (N = 106; BT = 51 and ALL = 55) identified as having attention defici...
| Publicado en: | Journal of Pediatric Psychology Vol. 35; no. 2; pp. 144 - 156 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Oxford University Press / USA
Mar2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105119301&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105119301 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01468693 3YD jtl: Journal of Pediatric Psychology issn: 01468693 maglogo: N pubinfo: dt: Mar2010 vid: 35 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105119301 NLM19465537 2010564960 10.1093/jpepsy/jsp044 NLM19465537 PMC2902831 105119301 ppf: 144 ppct: 12 formats: tig: atl: Predicting methylphenidate response in long-term survivors of childhood cancer: a randomized, double-blind, placebo-controlled, crossover trial. aug: au: Conklin HM Helton S Ashford J Mulhern RK Reddick WE Brown R Bonner M Jasper BW Wu S Xiong X Khan RB Conklin, Heather M Helton, Susan Ashford, Jason Mulhern, Raymond K Reddick, Wilburn E Brown, Ronald Bonner, Melanie Jasper, Bruce W Wu, Shengjie affil: Division of Behavioral Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105, USA sug: subj: Attention Drug Effects Brain Neoplasms Drug Therapy Dopamine Uptake Inhibitors Therapeutic Use Learning Disorders Drug Therapy Methylphenidate Therapeutic Use Leukemia, Lymphocytic, Acute Drug Therapy Adolescence Brain Neoplasms Epidemiology Child Cognition Drug Effects Comorbidity Crossover Design Dopamine Uptake Inhibitors Administration and Dosage Dose-Response Relationship, Drug Double-Blind Studies Female Human Learning Disorders Epidemiology Learning Disorders Psychosocial Factors Male Methylphenidate Administration and Dosage Leukemia, Lymphocytic, Acute Epidemiology Predictive Value of Tests Psychological Tests Severity of Illness Indices Survivors Psychosocial Factors Tennessee Treatment Outcomes Adolescent: 13-18 years Child: 6-12 years Female Male ab: Objective: To investigate the methylphenidate (MPH) response rate among childhood survivors of acute lymphoblastic leukemia (ALL) and brain tumors (BTs) and to identify predictors of positive MPH response.Methods: Cancer survivors (N = 106; BT = 51 and ALL = 55) identified as having attention deficits and learning problems participated in a 3-week, double-blind, crossover trial consisting of placebo, low-dose MPH (0.3 mg/kg), and moderate-dose MPH (0.6 mg/kg). Weekly teacher and parent reports on the Conners' Rating Scales were gathered.Results: Following moderate MPH dose, 45.28% of the sample was classified as responders. Findings revealed that more problems endorsed prior to the medication trial on parent and teacher ratings were predictive of positive medication response (p < .05).Conclusions: MPH significantly reduces attention problems in a subset of childhood cancer survivors. Parent and teacher ratings may assist in identifying children most likely to respond to MPH so prescribing may be optimally targeted. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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