Is there any difference between acetylator phenotypes in tuberculosis patients and healthy subjects?
BACKGROUND AND PURPOSE: Many studies have been done to determine the distribution of acetylator phenotypes among populations of different geographic origin. The goal of this study was to investigate the acetylator phenotypes of the Iranian population and compare them between tubercular patients and...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 66; no. 3; pp. 261 - 268 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105122391&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105122391 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Mar2010 vid: 66 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105122391 2010568431 10.1007/s00228-009-0745-1 NLM20187288 105122391 ppf: 261 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Is there any difference between acetylator phenotypes in tuberculosis patients and healthy subjects? aug: au: Khalili H Dashti-Khavidaki S Amini M Mahjub R Hajiabdolbaghi M affil: Department of Pharmacotherapy, School of Pharmacy, Tehran University of Medical Sciences, Tehran Iran sug: subj: Laboratory Chemicals Patient Care Methods Phenotype Tuberculosis Diagnosis Chromatography Methods Data Analysis Software Descriptive Statistics Funding Source Human Isoniazid Pharmacodynamics Isoniazid Therapeutic Use Pharmacy and Pharmacology Research Subjects Evaluation Tuberculosis Physiopathology ab: BACKGROUND AND PURPOSE: Many studies have been done to determine the distribution of acetylator phenotypes among populations of different geographic origin. The goal of this study was to investigate the acetylator phenotypes of the Iranian population and compare them between tubercular patients and healthy subjects. METHODS: The study population consisted of two groups; the first group included 100 newly diagnosed tubercular patients and the second group consisted of 100 healthy subjects. Acetylator phenotype was determined from the metabolic ratio of acetyl-isoniazid to isoniazid in the plasma samples. Metabolic ratio was used to classify subjects as slow (= or < 0.70) or fast acetylators (>0.70). RESULTS: In the tubercular patients, the frequencies of slow and fast acetylator phenotypes were 62 and 38%, respectively. Of the healthy individuals, 45% were found to be slow acetylators and the remaining 55% were fast acetylators. CONCLUSION: It seems that tubercular patients metabolize isoniazid more slowly than healthy individuals. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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