Low-Level CD4(+) T Cell Activation in HIV-Exposed Seronegative Subjects: Influence of Gender and Condom Use.
Immune activation has been suggested to increase susceptibility to human immunodeficiency virus type 1 (HIV-1) transmission, while at the same time it could be deemed essential for mounting an effective antiviral immune response. In this study, we compared levels of T cell activation between exposed...
| Publicado en: | Journal of Infectious Diseases Vol. 201; no. 6; pp. 835 - 843 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
3/15/2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105128988&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105128988 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00221899 1YU jtl: Journal of Infectious Diseases issn: 00221899 maglogo: N pubinfo: dt: 3/15/2010 vid: 201 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105128988 105128988 2010576289 10.1086/651000 NLM20136413 105128988 ppf: 835 ppct: 8 formats: tig: atl: Low-Level CD4(+) T Cell Activation in HIV-Exposed Seronegative Subjects: Influence of Gender and Condom Use. aug: au: Camara M Dieye TN Seydi M Diallo AA Fall M Diaw PA Sow PS Mboup S Kestens L Jennes W affil: Laboratory of Immunology, Department of Bacteriology-Virology, Centre Hospitalier Universitaire Le Dantec, and 2Department of Infectious Diseases, Centre Hospitalier Universitaire Fann, Cheikh Anta Diop University, Dakar, Senegal; 3Laboratory of Immunology, Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium. sug: subj: T Lymphocytes Immunology HIV Infections Immunology HIV Seronegativity Immunology HIV-1 Immunology Immunologic Techniques Adolescence Adult Antigens, Surface Blood Case Control Studies Condoms Utilization Female HIV Infections Blood HIV Infections Epidemiology HIV Infections Transmission Human Interviews Male Glycoproteins Blood Middle Age Senegal Demography Sexuality Young Adult Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Immune activation has been suggested to increase susceptibility to human immunodeficiency virus type 1 (HIV-1) transmission, while at the same time it could be deemed essential for mounting an effective antiviral immune response. In this study, we compared levels of T cell activation between exposed seronegative (ESN) partners in HIV-1 discordant couples and HIV-unexposed control subjects in Dakar, Senegal. ESN subjects showed lower levels of CD38 expression on CD4(+) T cells than did control subjects. However, this was found to be associated with concurrent differences in the use of condoms: ESN subjects reported a higher degree of condom use than did control subjects, which correlated inversely with CD38 expression. In addition, we observed markedly higher levels of T cell activation in women compared with men, irrespective of sexual behavior. These findings question the relevance of low-level CD4(+) T cell activation in resistance to HIV-1 infection and underscore the need to take gender and sexual behavior characteristics of high-risk populations into account when analyzing correlates of protective immunity. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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