Associations of serum concentrations of organochlorine pesticides with breast cancer and prostate cancer in U.S. adults.
Background: Organochlorine (OC) pesticides are a group of environmental endocrine disruptors that may be associated with an increased risk for hormone-related cancers including cancers of the breast and prostate. However, epidemiologic evidence is limited and inconsistent. Objectives and methods: We...
| Publicado en: | Environmental Health Perspectives Vol. 118; no. 1; pp. 60 - 67 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Jan2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105155900&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105155900 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Jan2010 vid: 118 iid: 1 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105155900 2010605533 10.1289/ehp.0900919 NLM20056587 PMC2831969 105155900 ppf: 60 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Associations of serum concentrations of organochlorine pesticides with breast cancer and prostate cancer in U.S. adults. aug: au: Xu X Dailey AB Talbott EO Ilacqua VA Kearney G Asal NR affil: Department of Epidemiology and Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, Florida; xhxu@phhp.ufl.edu sug: subj: Breast Neoplasms Risk Factors Hydrocarbons, Chlorinated Blood Pesticides Adverse Effects Prostatic Neoplasms Risk Factors Aged Chi Square Test Confidence Intervals Data Analysis Software Descriptive Statistics Female Human Logistic Regression Male Odds Ratio Spearman's Rank Correlation Coefficient T-Tests Aged: 65+ years Female Male ab: Background: Organochlorine (OC) pesticides are a group of environmental endocrine disruptors that may be associated with an increased risk for hormone-related cancers including cancers of the breast and prostate. However, epidemiologic evidence is limited and inconsistent. Objectives and methods: We used 1999-2004 National Health and Nutrition Examination Survey data to examine associations between serum concentrations of OC pesticides and prostate and breast cancers. Results: After adjustment for other covariates, serum concentrations of beta-hexachlorocyclohexane (HCH) (p for trend = 0.02), trans-nonachlor (p for trend = 0.002), and dieldrin (p for trend = 0.04) were significantly associated with the risk of prevalent prostate cancer. Adjusted odds ratios for the second and third tertiles of detectable values were 1.46 [95% confidence interval (CI), 0.52-4.13] and 3.36 (95% CI, 1.24-9.10) for beta-HCH; 5.84 (95% CI, 1.06-32.2) and 14.1 (95% CI, 2.55-77.9) for trans-nonachlor; and 1.06 (95% CI, 0.30-3.73) and 2.74 (95% CI, 1.01-7.49) for dieldrin compared with concentrations in the lowest tertile or below the limit of detection. However, there was no positive association between serum concentrations of OC pesticides and breast cancer prevalence. Conclusion: Although further study is necessary to confirm these findings, these results suggest that OC pesticide exposures may have a significant effect on cancer risk. Efforts to reduce worldwide OC use are warranted. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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