Internalizing versus externalizing comorbidity: neural circuit hypothesis.

The aim of the present study was to review and update historical controversies in relation to the limbic system in light of advances in the neuroanatmy and neurobiology of cortico-striatal-thalamic-cortical (CSTC) neural circuits. It is hypothesized that observed comorbidities between internalizing...

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Publicado en:Australian & New Zealand Journal of Psychiatry Vol. 44; no. 5; pp. 399 - 410
Autor principal: Levy F
Formato: tables/charts Journal Article
Publicado: Sage Publications Inc. May2010
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Sage Publications Inc.
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        atl: Internalizing versus externalizing comorbidity: neural circuit hypothesis.
      aug:
        au: Levy F
        affil: School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia; Child and Family East, Prince of Wales Hospital, Randwick, NSW 2031, Australia
      sug:
        subj:
          Cerebral Cortex Physiology
          Frontal Lobe Physiology
          Locus of Control
          Neuroanatomy
          Neurobiology
          Physiopathology
          Psychophysiology
          Stress Disorders, Post-Traumatic Physiopathology
          Comorbidity
          Limbic System
      ab: The aim of the present study was to review and update historical controversies in relation to the limbic system in light of advances in the neuroanatmy and neurobiology of cortico-striatal-thalamic-cortical (CSTC) neural circuits. It is hypothesized that observed comorbidities between internalizing and externalizing childhood syndromes may be better understood in terms of excess communication between subcortical brain circuits. A neuroanatomical understanding of reciprocal and non-reciprocal connections between modular circuits provides a basis for understanding previously puzzling aspects of internalizing, externalizing comorbidity. Function depends on the degree of cooperative integration of goal orientation, Pavlovian stimulus response, and operant processing in cortical-subcortical circuits, and interventions may be targeted at any of these functions.
      pubtype: Academic Journal
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        tables/charts
        Journal Article
      ougenre: Article
    language: English
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