A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects.
Purpose: Fenugreek seeds (Trigonella foenum-graecum L.) have long been used as a herbal medicine for treating metabolic and nutritive dysfunctions. They have been shown to modulate feeding behaviour in animals. We have recently observed a selective decrease in fat consumption in healthy normal weigh...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 66; no. 5; pp. 449 - 456 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105176882&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105176882 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: May2010 vid: 66 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105176882 2010628743 10.1007/s00228-009-0770-0 NLM20020282 105176882 ppf: 449 ppct: 7 formats: fmt: @attributes: type: P tig: atl: A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. aug: au: Chevassus H Gaillard J Farret A Costa F Gabillaud I Mas E Dupuy A Michel F Cantié C Renard E Galtier F Petit P affil: Centre d'Investigation Clinique, CHRU Montpellier, Montpellier France sug: subj: Fats Physiology Obesity Therapy Patient Care Methods Plants, Medicinal Therapeutic Use Analysis of Covariance Antioxidants Therapeutic Use Confidence Intervals Data Analysis Software Data Analysis Methods Descriptive Statistics Diabetes Mellitus Therapy Diet Evaluation Eating Behavior Evaluation Energy Intake Funding Source Human Insulin Therapeutic Use Male Pharmacy and Pharmacology Volunteer Workers Male ab: Purpose: Fenugreek seeds (Trigonella foenum-graecum L.) have long been used as a herbal medicine for treating metabolic and nutritive dysfunctions. They have been shown to modulate feeding behaviour in animals. We have recently observed a selective decrease in fat consumption in healthy normal weight volunteers treated with a hydroalcoholic seed extract. However, strong clinical data on the effects of fenugreek seeds on energy intake are lacking, especially in overweight individuals. The aim of our study was to investigate the effects of a repeated administration of a fenugreek seed extract on the eating behaviour of overweight subjects. Methods: Thirty-nine healthy overweight male volunteers completed a 6-week double-blind randomized placebocontrolled parallel trial of a fixed dose of a fenugreek seed extract. Main endpoints were energy intake (dietary records and meal test), weight, fasting and post-absorptive glucose and insulin, appetite/satiety scores and oxidative parameters. Results: Daily fat consumption, expressed as the ratio fat reported energy intake/total energy expenditure (fat-REI/ TEE), was significantly decreased in our overweight subjects administered the fenugreek seed extract relative to those receiving the placebo (fat-REI/TEE 0.26±0.02 vs. 0.30±0.01, respectively; P=0.032). We also observed a significant decrease in the insulin/glucose ratio in subjects treated with fenugreek seed extract relative to the placebo group (0.89±0.09 vs. 1.06±0.10 mUI mmol-1, respectively; P=0.044). No significant effect was observed on weight, appetite/satiety scores or oxidative parameters. Conclusion: The repeated administration of a fenugreek seed extract slightly but significantly decreased dietary fat consumption in healthy overweight subjects in this shortterm study. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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