Phenotypic and genetic characterization of antimicrobial profiles of Helicobacter pylori strains in Cuba.
The study evaluated the antibiotic resistance patterns of Helicobacter pylori strains against metronidazole and clarithromycin in a hospital in Havana, Cuba. Eighty-five percent, 22.5%, and 10% of 40 H. pylori strains investigated were resistant to metronidazole, ciprofloxacin, and clarithromycin re...
| Publicado en: | Journal of Health, Population & Nutrition Vol. 28; no. 2; pp. 124 - 130 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
Apr2010
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105181475&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105181475 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16060997 HII jtl: Journal of Health, Population & Nutrition issn: 16060997 maglogo: N pubinfo: dt: Apr2010 vid: 28 iid: 2 pid: 24147 pub: BioMed Central artinfo: ui: 105181475 NLM20411674 2010634048 10.3329/jhpn.v28i2.4881 NLM20411674 105181475 ppf: 124 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Phenotypic and genetic characterization of antimicrobial profiles of Helicobacter pylori strains in Cuba. aug: au: Llanes R Soria C Nagashima S Kobayashi N Gala A Guzmán D Feliciano O Valdés L Gutiérrez O Fernández H Llop A Wada A Llanes, Rafael Soria, Claudia Nagashima, Shigeo Kobayashi, Nobumichi Gala, Angela Guzmán, Daymi Feliciano, Onelkis Valdés, Lidunka affil: Microbiology, Clinical and Epidemiology Branch, Institute Pedro Kouri, Havana, Cuba sug: subj: Antibiotics Pharmacodynamics Antiinfective Agents Pharmacodynamics Helicobacter Pylori Drug Effects Helicobacter Pylori Mutation Adult Age Factors Aged Amoxicillin Pharmacodynamics Ciprofloxacin Pharmacodynamics Clarithromycin Pharmacodynamics Cuba Drug Resistance, Microbial Female Helicobacter Pylori Classification Human Male Metronidazole Pharmacodynamics Microbial Culture and Sensitivity Tests Methods Middle Age Polymerase Chain Reaction Methods Sequence Analysis Methods Sex Factors Immunity Tetracycline Pharmacodynamics Young Adult Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: The study evaluated the antibiotic resistance patterns of Helicobacter pylori strains against metronidazole and clarithromycin in a hospital in Havana, Cuba. Eighty-five percent, 22.5%, and 10% of 40 H. pylori strains investigated were resistant to metronidazole, ciprofloxacin, and clarithromycin respectively but all were susceptible to amoxicillin and tetracycline. RdxA truncation was found only in metronidazole-resistant strains. In such strains, reported are eight and two novel mutations in the rdxA and frxA genes respectively. Two-point mutations in the 23S rRNA genes of clarithromycin-resistant strains were detected. A high prevalence of metronidazole resistance was found in Cuban H. pylori strains. Mutations in the rdxA gene may contribute more significantly than frxA gene to the high level of resistance to metronidazole. This study supports the need to continue monitoring the antibiotic susceptibility in H. pylori in Cuba to guide the treatment of such infection. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|