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The spatial distribution of otosclerosis: a quantitative study using design-based stereology.

Conclusion: This study documents that otosclerotic bone remodeling is distributed centripetally around the inner ear space whereas normal bone remodeling is distributed centrifugally. We suggest that this inverse relation reflects the unique osteo-dynamic setting of the otic capsule: since perilabyr...

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Published in:Acta Oto-Laryngologica Vol. 130; no. 5; pp. 532 - 540
Main Authors: Bloch SL, Sørensen MS
Format: equations & formulas research tables/charts Journal Article
Published: Taylor & Francis Ltd May2010
Online Access:View this record in EBSCOhost
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        atl: The spatial distribution of otosclerosis: a quantitative study using design-based stereology.
      aug:
        au:
          Bloch SL
          Sørensen MS
        affil: Department of Otolaryngology Head and Neck Surgery F2074, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark. E-mail: SuneBloch@hotmail.com
      sug:
        subj:
          Bone Remodeling Evaluation
          Otosclerosis Physiopathology
          Adult
          Aged
          Aged, 80 and Over
          Analysis of Variance
          Connective Tissue Cells
          Female
          Funding Source
          Human
          Ear, Inner Anatomy and Histology
          Male
          Middle Age
          Post Hoc Analysis
          Quantitative Studies
          Repeated Measures
          Software
          Adult: 19-44 years
          Aged: 65+ years
          Aged, 80 & over
          Middle Aged: 45-64 years
          Female
          Male
      ab: Conclusion: This study documents that otosclerotic bone remodeling is distributed centripetally around the inner ear space whereas normal bone remodeling is distributed centrifugally. We suggest that this inverse relation reflects the unique osteo-dynamic setting of the otic capsule: since perilabyrinthine bone remodeling is extremely low, osteocyte deficiency and microcracks accumulate in excess toward the inner ear space with age. This may disrupt the osseus functional network, impede propagation of anti-resorptive signals, and precipitate otosclerotic bone remodeling with a spatial preference for older bone. Objective: To quantify the spatial distribution of otosclerotic bone around the inner ear space in order to explore a possible spatial relation with normal capsular bone remodeling. Methods: Otosclerotic lesions in 53 undecalcified human temporal bones were identified and volume data were measured with the CAST-grid system and processed by dedicated software for advanced design-based stereology. Results: The maximum volume fraction of otosclerotic bone was observed in the innermost perilabyrinthine zones of the otic capsule. The volume fraction of otosclerotic bone declined gradually but significantly from the inner ear space towards the capsular periphery with a general perilabyrinthine centripetal distribution.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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