Screening for autism spectrum disorders in children with Down syndrome: population prevalence and screening test characteristics.
Objective: We assessed the prevalence of autism spectrum disorders (ASD) and screening test characteristics in children with Down syndrome.Method: Eligible children born in a defined geographic area between January 1, 1996, and December 31, 2003, were recruited through a population-based birth defec...
| Publicado en: | Journal of Developmental & Behavioral Pediatrics Vol. 31; no. 3; pp. 181 - 192 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2010 Apr
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105186455&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105186455 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0196206X 8CM jtl: Journal of Developmental & Behavioral Pediatrics issn: 0196206X maglogo: N pubinfo: dt: 2010 Apr vid: 31 iid: 3 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105186455 105186455 NLM20375732 2010639599 10.1097/DBP.0b013e3181d5aa6d NLM20375732 PMC4419691 105186455 ppf: 181 ppct: 11 formats: tig: atl: Screening for autism spectrum disorders in children with Down syndrome: population prevalence and screening test characteristics. aug: au: DiGuiseppi C Hepburn S Davis JM Fidler DJ Hartway S Lee NR Miller L Ruttenber M Robinson C DiGuiseppi, Carolyn Hepburn, Susan Davis, Jonathan M Fidler, Deborah J Hartway, Sara Lee, Nancy Raitano Miller, Lisa Ruttenber, Margaret Robinson, Cordelia affil: Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO 80045, USA sug: subj: Child Development Disorders, Pervasive Diagnosis Child Development Disorders, Pervasive Epidemiology Down Syndrome Diagnosis Down Syndrome Epidemiology Child Child, Preschool Cognition Disorders Diagnosis Cognition Disorders Epidemiology Prospective Studies Colorado Cross Sectional Studies Female Human Male Health Screening Methods Prevalence Questionnaires Sensitivity and Specificity Checklists Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Objective: We assessed the prevalence of autism spectrum disorders (ASD) and screening test characteristics in children with Down syndrome.Method: Eligible children born in a defined geographic area between January 1, 1996, and December 31, 2003, were recruited through a population-based birth defects registry and community outreach, then screened with the modified checklist for autism in toddlers or social communication questionnaire, as appropriate. Screen-positive children and a random sample of screen-negative children underwent developmental evaluation.Results: We screened 123 children (27.8% of the birth cohort). Mean age was 73.4 months (range, 31-142). Compared to screen-negative children, screen-positive children had similar sociodemographic characteristics but a lower mean developmental quotient (mean difference: 11.0; 95% confidence interval: 4.8-17.3). Weighted prevalences of autistic disorder and total ASD were 6.4% (95% confidence interval [CI]: 2.6%-11.6%) and 18.2% (95% CI: 9.7%-26.8%), respectively. The estimated minimum ASD prevalence, accounting for unscreened children, is 5.1% (95% CI: 3.3%-7.4%). ASD prevalence increased with greater cognitive impairment. Screening test sensitivity was 87.5% (95% CI: 66.6%-97.7%); specificity was 49.9% (95% CI: 37.0%-61.4%).Conclusion: The prevalence of ASD among children with Down syndrome aged 2 to 11 years is substantially higher than in the general population. The modified checklist for autism in toddlers and social communication questionnaire were highly sensitive in children with Down syndrome but could result in many false positive tests if universal screening were implemented using current algorithms. Research needs include development of specific ASD screening algorithms and improved diagnostic discrimination in children with Down syndrome. Timely identification of these co-occurring diagnoses is essential so appropriate interventions can be provided. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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