Pulmonary kinematics from tagged hyperpolarized helium-3 MRI.
Purpose: To propose and test the feasibility of a novel method for quantifying 3D regional pulmonary kinematics from hyperpolarized helium-3 tagged MRI in human subjects using a tailored image processing pipeline and a recently developed nonrigid registration framework.Materials and Methods: Followi...
| Published in: | Journal of Magnetic Resonance Imaging Vol. 31; no. 5; pp. 1236 - 1242 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Wiley-Blackwell
May2010
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105188114&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105188114 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10531807 O63 jtl: Journal of Magnetic Resonance Imaging issn: 10531807 maglogo: Y pubinfo: dt: May2010 vid: 31 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105188114 NLM20432362 2010640923 10.1002/jmri.22137 NLM20432362 PMC2997045 105188114 ppf: 1236 ppct: 6 formats: tig: atl: Pulmonary kinematics from tagged hyperpolarized helium-3 MRI. aug: au: Tustison NJ Awate SP Cai J Altes TA Miller GW de Lange EE Mugler JP 3rd Gee JC Tustison, Nicholas J Awate, Suyash P Cai, Jing Altes, Talissa A Miller, G Wilson de Lange, Eduard E Mugler, John P 3rd Gee, James C affil: Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA sug: subj: Contrast Media Administration and Dosage Helium Administration and Dosage Helium Diagnostic Use Lung Pathology Magnetic Resonance Imaging Methods Respiratory Function Tests Methods Administration, Inhalation Female Human Isotopes Administration and Dosage Isotopes Diagnostic Use Male Reproducibility of Results Sensitivity and Specificity Female Male ab: Purpose: To propose and test the feasibility of a novel method for quantifying 3D regional pulmonary kinematics from hyperpolarized helium-3 tagged MRI in human subjects using a tailored image processing pipeline and a recently developed nonrigid registration framework.Materials and Methods: Following image acquisition, inspiratory and expiratory tagged (3)He magnetic resonance (MR) images were preprocessed using various image filtering techniques to enhance the tag surfaces. Segmentation of the three orthogonal sets of tag planes in each lung produced distinct point-set representations of the tag surfaces. Using these labeled point-sets, deformation fields and corresponding strain maps were obtained via nonrigid point-set registration. Kinematic analysis was performed on three volunteers.Results: Tag lines in inspiratory and expiratory images were coregistered producing a continuous 3D correspondence mapping. Average displacement and directional strains were calculated in three subjects in the inferior, mid, and superior portions of the right and left lungs. As expected, the predominant direction of displacements with expiration is from inferior to superior.Conclusion: Kinematic quantitation of pulmonary motion using tagged (3)He MRI is feasible using the applied image preprocessing filtering techniques and nonrigid point-set registration. Potential benefits from regional pulmonary kinematic quantitation include the facilitation of diagnosis and local assessment of disease progression. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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