Paediatric chronic liver diseases: how to investigate and follow up? Role of imaging in the diagnosis of fibrosis.

Chronic liver diseases are rare in children, but encompass a wide spectrum of disorders that may all be complicated by liver fibrosis and therefore by portal hypertension. They may be classified according to the level of portal flow obstruction: prehepatic, intrahepatic or suprahepatic. Most of them...

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Publicado en:Pediatric Radiology Vol. 40; no. 6; pp. 906 - 920
Autores principales: Pariente D, Franchi-Abella S, Pariente, Danièle, Franchi-Abella, Stéphanie
Formato: research Journal Article
Publicado: Springer Nature Jun2010
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
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        atl: Paediatric chronic liver diseases: how to investigate and follow up? Role of imaging in the diagnosis of fibrosis.
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          Pariente D
          Franchi-Abella S
          Pariente, Danièle
          Franchi-Abella, Stéphanie
        affil: Pediatric Radiology Department, Bicêtre Hospital, Assistance Publique Hôpitaux de Paris, University Paris XI, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre, France
      sug:
        subj:
          Diagnostic Imaging Methods
          Image Enhancement Methods
          Liver Cirrhosis Diagnosis
          Child
          Chronic Disease
          Prospective Studies
          Human
          Child: 6-12 years
      ab: Chronic liver diseases are rare in children, but encompass a wide spectrum of disorders that may all be complicated by liver fibrosis and therefore by portal hypertension. They may be classified according to the level of portal flow obstruction: prehepatic, intrahepatic or suprahepatic. Most of them, except presinusoidal diseases, may progress to cirrhosis that carries additional risks of impaired liver function and development of hepatocellular carcinoma. Imaging plays an important role in guiding the diagnosis and biopsy and for follow-up during treatment. US, with high-frequency transducers and Doppler, is the first modality of choice, directs the rest of the investigations and guides interventional radiology. MDCT has made great progress and has replaced angiography for diagnostic purposes. MRI is indicated for parenchyma and nodule characterization and for biliary tract evaluation. To avoid liver biopsy, several elasticity imaging techniques have been developed and have to be evaluated for accuracy and convenience in children. The role of each modality with main imaging findings is described in extrahepatic portal vein obstruction, hepatoportal sclerosis, congenital hepatic fibrosis, cirrhosis and Budd-Chiari syndrome.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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