Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori.
Objectives: Cytotoxic associated gene-A (CagA)-positive strains of Helicobacter pylori emerged as a possible atherosclerotic stimulus. Nevertheless, whether CagA-positivity is associated with more extensive or severe atherosclerotic coronary burden has never been studied. Methods: Forty consecutive...
| Publicado en: | Coronary Artery Disease Vol. 21; no. 4; pp. 217 - 222 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2010 Jun
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105193853&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105193853 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09546928 GPJ jtl: Coronary Artery Disease issn: 09546928 maglogo: N pubinfo: dt: 2010 Jun vid: 21 iid: 4 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 105193853 105193853 NLM20389238 2010647302 10.1097/MCA.0b013e3283399f36 NLM20389238 105193853 ppf: 217 ppct: 5 formats: tig: atl: Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori. aug: au: Niccoli G Franceschi F Cosentino N Giupponi B De Marco G Merra G Conte M Montone RA Ferrante G Bacà M Gasbarrini A Silveri NG Crea F Niccoli, Giampaolo Franceschi, Francesco Cosentino, Nicola Giupponi, Bianca De Marco, Guido Merra, Giuseppe Conte, Micaela affil: Institute of Cardiology, Catholic University of Sacred Heart, Rome, Italy sug: subj: Antibodies, Bacterial Blood Antigens, Bacterial Immunology Bacterial Proteins Immunology Coronary Arteriosclerosis Microbiology Helicobacter Infections Microbiology Helicobacter Pylori Immunology Aged Case Control Studies Coronary Angiography Coronary Arteriosclerosis Complications Coronary Arteriosclerosis Radiography Female Helicobacter Infections Complications Human Male Middle Age Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: Cytotoxic associated gene-A (CagA)-positive strains of Helicobacter pylori emerged as a possible atherosclerotic stimulus. Nevertheless, whether CagA-positivity is associated with more extensive or severe atherosclerotic coronary burden has never been studied. Methods: Forty consecutive patients with coronary artery disease (CAD) and twenty consecutive patients with normal coronary arteries undergoing coronary angiography were enrolled. All patients underwent evaluation of classical atherogenic risk factors and assessment of anti-urease B and anti-CagA antibodies titer. Either the severity of coronary stenosis (stenosis score) or the extent of coronary atherosclerosis (extent score) was evaluated in CAD patients. Results: The anti-CagA antibody titer was significantly higher in patients with CAD as compared with normal coronary arteries patients [85 (10-108.75) vs. 47.3 (17-64) RU/ml, P=0.02], whereas there were no differences in anti-urease B titer between the two groups. A significant correlation was found between anti-CagA antibody titer and extent score (R=0.35, P=0.03), whereas stenosis score was similar (R=0.25, P=0.11). On the contrary, no significant correlation was found between anti-urease B antibody titer and either extent or stenosis score. Moreover, CagA-positive patients had a more extensive CAD (P=0.029) when compared with CagA-negative patients. Interestingly, whereas serum glucose, LDL levels, anti-urease B, and anti-CagA antibodies were predictors of extent score at univariate analysis, at multivariate analysis anti-CagA antibody titer only was an independent predictor of the extent of coronary atherosclerosis (B=0.051, standard error of B=0.042, P=0.04). Conclusion: These results support the association between CagA-positive H. pylori infection and coronary atherosclerotic burden. Further studies are needed to better elucidate the mechanism by which CagA-positive strains may promote atherosclerosis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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