Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study)
Background and object: An antiulcer agent, ecabet sodium, is active against Helicobacter pylori. The aim of the present study was to clinically examine whether eradication therapy, which includes ecabet sodium, is effective in eradication of H. pylori after failure of first-line therapy. Methods: Pa...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 35; no. 3; pp. 303 - 308 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105196126&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105196126 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Jun2010 vid: 35 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105196126 105196126 2010649936 10.1111/j.1365-2710.2009.01092.x NLM20831531 105196126 ppf: 303 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study) aug: au: Koizumi W Tanabe S Nakatani K Ishido K Nishimura K Azuma M Ae T Sasaki T Higuchi K Katada C Nakayama N Saigenji K affil: Department of Gastroenterology, Kitasato University School of Medicine, 2-1-1 Asamizodai, Sagamihara-shi, Kanagawa-ken 228-8520, Japan; koizumi@med.kitasato-u.ac.jp sug: subj: Amoxicillin Administration and Dosage Antiulcer Agents Administration and Dosage Helicobacter Infections Drug Therapy Metronidazole Administration and Dosage Omeprazole Administration and Dosage Adult Aged Drug Therapy, Combination Female Fisher's Exact Test Human Interviews Japan Male Middle Age Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background and object: An antiulcer agent, ecabet sodium, is active against Helicobacter pylori. The aim of the present study was to clinically examine whether eradication therapy, which includes ecabet sodium, is effective in eradication of H. pylori after failure of first-line therapy. Methods: Patients with peptic ulcer who failed with first-line triple eradication therapy containing clarithromycin received quadruple therapy with omeprazole (20 mg, twice daily), amoxicillin (750 mg, twice daily), metronidazole (500 mg, twice daily) and ecabet sodium (1000 mg, twice daily) for 14 days. Eradication of H. pylori was judged by (13)C-urea breath test 8 weeks later. Results: Fifty-two patients (36 men and 16 women) were included. Their mean age was 51·4 years (range 28-73). One patient dropped out because of diarrhoea. The eradication rate was 98·0% (50/51) according to the per-protocol analysis and 96·2% (50/52) according to the intention-to-treat analysis. Side effects occurred in seven patients, but none were serious. Conclusions: Quadruple therapy including ecabet sodium is useful as second-line eradication treatment for H. pylori. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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