Deep partial thickness burn blister fluid promotes neovascularization in the early stage of burn wound healing.
The effect of burn blister fluid in neovascularization during burn wound healing is unknown. Burn blister fluid, containing a large amount of chemokines, is thought to play a role in the early stage of neovascularization. This process includes angiogenesis and vasculogenesis. Because of different he...
| Publicado en: | Wound Repair & Regeneration Vol. 18; no. 3; pp. 311 - 319 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
May/Jun2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105202708&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105202708 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: May/Jun2010 vid: 18 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105202708 2010657000 10.1111/j.1524-475X.2010.00586.x NLM20412554 105202708 ppf: 311 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Deep partial thickness burn blister fluid promotes neovascularization in the early stage of burn wound healing. aug: au: Pan S Wu L Chen C Shieh S Chiu H affil: Institute of Molecular Medicine and Cardiovascular Research Center, College of Medicine, National Cheng Kung University, Tainan, Taiwan sug: subj: Blister Burns Physiopathology Fluids and Secretions Neovascularization, Physiologic Wound Healing Physiology Adolescence Adult Aged Chemokines Child Child, Preschool Descriptive Statistics Funding Source Human Immunohistochemistry In Vitro Studies Middle Age One-Way Analysis of Variance Polymerase Chain Reaction Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Child: 6-12 years Child, Preschool: 2-5 years Middle Aged: 45-64 years ab: The effect of burn blister fluid in neovascularization during burn wound healing is unknown. Burn blister fluid, containing a large amount of chemokines, is thought to play a role in the early stage of neovascularization. This process includes angiogenesis and vasculogenesis. Because of different healing time of burn wounds, we hypothesized that neovascularization in superficial partial thickness burn (SPTB) and deep partial thickness burn (DPTB) wounds were different. The neovasculogenic effects of two different burn blister fluids were also different. We found Day 7 DPTB wounds had a significant increase in blood vessels compared with SPTB wounds by immunohistochemistry. DPTB blister fluid significantly promoted neovascularization via increasing endothelial cell proliferation, and migration and differentiation of circulating angiogenic cells relative to SPTB blister fluids. In the animal study, DPTB blister fluids markedly promoted new blood vessel formation compared with those from SPTB blister fluids using in vivo Matrigel plug assay. These results suggest that DPTB wounds require more new vessel formation than SPTB. Furthermore, the measurement of angiogenic activities in burn blister fluids serves as a possible tool for assessing burn wound status. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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