Characterization of a test for invasive breast cancer using X-ray diffraction of hair---results of a clinical trial.
Objective: To assess the performance of a test for breast cancer utilizing synchrotron x-ray diffraction analysis of scalp hair from women undergoing diagnostic radiology assessment. Design and Setting: A double-blinded clinical trial of women who attended diagnostic radiology clinics in Australia....
| Publicado en: | Breast Cancer: Basic & Clinical Research no. 3; pp. 83 - 91 |
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| Autores principales: | , , , , , , , |
| Formato: | clinical trial diagnostic images research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105203594&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105203594 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11782234 B078 jtl: Breast Cancer: Basic & Clinical Research issn: 11782234 maglogo: Y pubinfo: dt: 2009 iid: 3 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 105203594 105203594 2010657897 105203594 ppf: 83 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Characterization of a test for invasive breast cancer using X-ray diffraction of hair---results of a clinical trial. aug: au: Corino GL French PW Lee M Ajaj MM Haklani J Mistry DAH Phan K Yuile PG affil: Fermiscan Pty Ltd, 48 Hunter Street, Sydney, NSW, Australia sug: subj: Breast Neoplasms Diagnosis Comparative Studies Hair Radiography Mammography Ultrasonography Age Factors Australia Breast Neoplasms Chi Square Test Clinical Trials Double-Blind Studies Equipment and Supplies Funding Source Human Odds Ratio Sensitivity and Specificity ab: Objective: To assess the performance of a test for breast cancer utilizing synchrotron x-ray diffraction analysis of scalp hair from women undergoing diagnostic radiology assessment. Design and Setting: A double-blinded clinical trial of women who attended diagnostic radiology clinics in Australia. Patients: 1796 women referred for diagnostic radiology, with no previous history of cancer. Main Outcome Measures: Sensitivity, specificity and accuracy of the hair test analysis compared to the gold standard of imaging followed by biopsy where indicated. Results: The hair-based assay had an overall accuracy of ?77% and a negative predictive value of 99%. For all women, the sensitivity of both mammography and X-ray diffraction alone was 64%, but when used together the sensitivity rose to 86%. The sensitivity of the hair test for women under the age of 70 was 74%. Conclusion: In this large population trial the association between the presence of breast cancer and an altered hair fibre X-ray diffraction pattern previously reported has been confirmed. It appears that mammography and X-ray diffraction of hair detect different populations of breast cancers, and are synergistic when used together. pubtype: Academic Journal doctype: clinical trial diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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