An onco-informatics database for anticancer drug interactions with complementary and alternative medicines used in cancer treatment and supportive care: an overview of the OncoRx project.
Purpose: Cancer patients are at high risk of manifesting interactions from use of anticancer drugs (ACDs) and complementary and alternative medicines (CAMs). These interactions can result in sub-therapeutic effects or increased toxicities which may compromise the outcome of chemotherapy. It is impor...
| Publicado en: | Supportive Care in Cancer Vol. 18; no. 7; pp. 883 - 892 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jul2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105206968&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105206968 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Jul2010 vid: 18 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105206968 50721474 NLM19756775 2010662813 10.1007/s00520-009-0729-9 NLM19756775 105206968 ppf: 883 ppct: 9 formats: fmt: @attributes: type: P tig: atl: An onco-informatics database for anticancer drug interactions with complementary and alternative medicines used in cancer treatment and supportive care: an overview of the OncoRx project. aug: au: Yap KY Kuo EY Lee JJ Chui WK Chan A Yap, Kevin Yi-Lwern Kuo, En Yi Lee, Jonathan Jun Jie Chui, Wai Keung Chan, Alexandre affil: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore sug: subj: Antineoplastic Agents Administration and Dosage Alternative Therapies Resource Databases Drug-Herb Interactions Neoplasms Therapy Alopecia Etiology Alopecia Prevention and Control Antineoplastic Agents Classification Combined Modality Therapy Data Display Fatigue Syndrome, Chronic Etiology Fatigue Syndrome, Chronic Prevention and Control Immunologic Diseases Etiology Immunologic Diseases Prevention and Control Inflammation Etiology Inflammation Prevention and Control Internet Medicine, Chinese Traditional Methods Nausea Etiology Nausea Prevention and Control Neoplasms Complications Pain Etiology Pain Prevention and Control Palliative Care Plants, Medicinal Classification Support, Psychosocial User-Computer Interface ab: Purpose: Cancer patients are at high risk of manifesting interactions from use of anticancer drugs (ACDs) and complementary and alternative medicines (CAMs). These interactions can result in sub-therapeutic effects or increased toxicities which may compromise the outcome of chemotherapy. It is important for practitioners to gain convenient access to ACD-CAM interaction information so as to make better-informed decisions in daily practice. This paper describes the creation of an oncology database (OncoRx) that documents ACD-CAM interactions, including traditional Chinese medicines (TCMs) that are commonly used for cancer treatment, prevention, and supportive care therapy.Methods: Information regarding ACDs, CAMs, and drug interactions were collated from 14 sources, inclusive of hardcopy and online resources, and input into a modified web server with a database engine and a programming interface using a combination of software and programming scripts.Results: OncoRx currently contains a total of 117 ACDs and 166 CAMs. Users are able to search for interactions based on various CAM uses: cancer treatment or prevention, immune-system-related, alopecia, nausea, and vomiting, peripheral neuropathy and pain, inflammation, fatigue, and non-cancer related. Pharmacokinetic data on ACDs and CAMs, characteristics of CAMs based on TCM principles, and drug interaction parameters such as effects, mechanisms, evidences, and proposed management plans, are shown in the search results.Conclusion: OncoRx is an oncology database which detects ACD interactions. It is currently able to detect interactions with CAMs. It is hoped that OncoRx will serve as a useful resource to clinicians, educators, trainers, and students working in the oncology setting. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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