Postmenopausal hormones and sleep quality in the elderly: a population based study.
Background: Sleep disturbance and insomnia are commonly reported by postmenopausal women. However, the relationship between hormone therapy (HT) and sleep disturbances in postmenopausal community-dwelling adults is understudied. Using data from the multicenter Study of Osteoporotic Fractures (SOF),...
| Publicado en: | BMC Women's Health Vol. 10; pp. 15 - 16 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105213164&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105213164 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726874 1CIP jtl: BMC Women's Health issn: 14726874 maglogo: N pubinfo: dt: 2010 vid: 10 pid: 24147 pub: BioMed Central artinfo: ui: 105213164 NLM20441593 2010669756 10.1186/1472-6874-10-15 NLM20441593 PMC2876067 105213164 ppf: 15 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Postmenopausal hormones and sleep quality in the elderly: a population based study. aug: au: Tranah GJ Parimi N Blackwell T Ancoli-Israel S Ensrud KE Cauley JA Redline S Lane N Paudel ML Hillier TA Yaffe K Cummings SR Stone KL Tranah, Gregory J Parimi, Neeta Blackwell, Terri Ancoli-Israel, Sonia Ensrud, Kristine E Cauley, Jane A Redline, Susan affil: CPMC Research Institute, San Francisco, CA, USA sug: subj: Hormone Replacement Therapy Postmenopause Drug Effects Postmenopause Physiology Sleep Disorders Drug Therapy Sleep Disorders Etiology Aged Aged, 80 and Over Analysis of Variance Prospective Studies Female Human Logistic Regression United States Aged: 65+ years Aged, 80 & over Female ab: Background: Sleep disturbance and insomnia are commonly reported by postmenopausal women. However, the relationship between hormone therapy (HT) and sleep disturbances in postmenopausal community-dwelling adults is understudied. Using data from the multicenter Study of Osteoporotic Fractures (SOF), we tested the relationship between HT and sleep-wake estimated from actigraphy.Methods: Sleep-wake was ascertained by wrist actigraphy in 3,123 women aged 84 +/- 4 years (range 77-99) from the Study of Osteoporotic Fractures (SOF). This sample represents 30% of the original SOF study and 64% of participants seen at this visit. Data were collected for a mean of 4 consecutive 24-hour periods. Sleep parameters measured objectively included total sleep time, sleep efficiency (SE), sleep latency, wake after sleep onset (WASO), and nap time. All analyses were adjusted for potential confounders (age, clinic site, race, BMI, cognitive function, physical activity, depression, anxiety, education, marital status, age at menopause, alcohol use, prior hysterectomy, and medical conditions).Results: Actigraphy measurements were available for 424 current, 1,289 past, and 1,410 never users of HT. Women currently using HT had a shorter WASO time (76 vs. 82 minutes, P = 0.03) and fewer long-wake (> or = 5 minutes) episodes (6.5 vs. 7.1, P = 0.004) than never users. Past HT users had longer total sleep time than never users (413 vs. 403 minutes, P = 0.002). Women who never used HT had elevated odds of SE <70% (OR,1.37;95%CI,0.98-1.92) and significantly higher odds of WASO > or = 90 minutes (OR,1.37;95%CI,1.02-1.83) and > or = 8 long-wake episodes (OR,1.58;95%CI,1.18-2.12) when compared to current HT users.Conclusions: Postmenopausal women currently using HT had improved sleep quality for two out of five objective measures: shorter WASO and fewer long-wake episodes. The mechanism behind these associations is not clear. For postmenopausal women, starting HT use should be considered carefully in balance with other risks since the vascular side-effects of hormone replacement may exceed its beneficial effects on sleep. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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