Retraction and fibroplasia in a polypropylene prosthesis: experimental study in rats.
Background: The treatment of hernia, independent of anatomical site and technique utilized, generally involves using prostheses, which may cause complications, despite their unarguable advantage in allowing safe reinforcement. An example of this is possible retraction, which causes discomfort and he...
| Publicado en: | Hernia Vol. 14; no. 3; pp. 291 - 299 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105217465&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105217465 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 12654906 NQ8 jtl: Hernia issn: 12654906 maglogo: N pubinfo: dt: Jun2010 vid: 14 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105217465 NLM20035361 2010674614 10.1007/s10029-009-0607-x NLM20035361 105217465 ppf: 291 ppct: 8 formats: tig: atl: Retraction and fibroplasia in a polypropylene prosthesis: experimental study in rats. aug: au: Zogbi L Portella AO Trindade MR Trindade EN Zogbi, L Portella, A O V Trindade, M R M Trindade, E N affil: Department of Surgery, Division of Gastrointestinal Surgery, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil sug: subj: Abdomen Pathology Abdomen Surgery Biocompatible Materials Polyenes Prostheses and Implants Wound Healing Animals Models, Biological Fascia Pathology Fascia Surgery Fibrosis Male Rats Surgical Mesh Male ab: Background: The treatment of hernia, independent of anatomical site and technique utilized, generally involves using prostheses, which may cause complications, despite their unarguable advantage in allowing safe reinforcement. An example of this is possible retraction, which causes discomfort and hernia recurrence. Polypropylene is still the most often used biomaterial of the great number available. The purpose of this study is to evaluate the amount of retraction of the polypropylene mesh, as well as the histological reactions that accompany this phenomenon.Methods: Polypropylene meshes (Marlex) were inserted in an anterior position to the whole abdominal aponeurosis of 25 Wistar rats (Rattus norvegicus albinus). The animals were divided into groups and another intervention was performed 7, 28, and 90 days later to measure the dimensions of the prostheses and to calculate the final area. Histological analysis was performed with hematoxylin-eosin to evaluate neutrophils, macrophages, giant cells, and lymphocytes surrounding the mesh threads in ten random fields of each slide.Results: Seven days after the mesh was inserted, the mean rate of retraction was 1.75% (P = 0.64); at 28 days, it was 3.75% (P = 0.02); and at 90 days, it was 2.5% (P = 0.01). As to the histological analysis, there was a total decline of neutrophils and a progressive increase of macrophages, giant cells, and lymphocytes proportional to the post-implant time of the mesh (P < 0.05).Conclusion: There was a statistically significant retraction of 3.75% at 28 days and 2.5% at 90 days after the prosthesis was inserted. There is a well-established sequence of cellular events which aim at synthesizing new connective tissue to reinforce the mesh. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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