Short-term triple therapy with azithromycin for Helicobacter pylori eradication: low cost, high compliance, but low efficacy.
Background: The Brazilian consensus recommends a short-term treatment course with clarithromycin, amoxicillin and proton-pump inhibitor for the eradication of Helicobacter pylori (H. pylori). This treatment course has good efficacy, but cannot be afforded by a large part of the population. Azithromy...
| Publicado en: | BMC Gastroenterology Vol. 8; pp. 20 - 21 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105218511&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105218511 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1471230X 1CHO jtl: BMC Gastroenterology issn: 1471230X maglogo: N pubinfo: dt: 2008 vid: 8 pid: 24147 pub: BioMed Central artinfo: ui: 105218511 NLM18510773 2010133171 10.1186/1471-230X-8-20 NLM18510773 105218511 ppf: 20 ppct: 1 formats: tig: atl: Short-term triple therapy with azithromycin for Helicobacter pylori eradication: low cost, high compliance, but low efficacy. aug: au: Silva FM Eisig JN Teixeira AC Barbuti RC Navarro-Rodriguez T Mattar R Silva, Fernando M Eisig, Jaime N Teixeira, Ana Cristina S Barbuti, Ricardo C Navarro-Rodriguez, Tomás Mattar, Rejane affil: Serviço de Gastroenterologia Clínica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av, Dr, Enéas de Carvalho Aguiar, 155, 9 degree, Andar, Cerqueira Cezar, São Paulo, SP, CEP: 05 403-900, Brasil sug: subj: Azithromycin Administration and Dosage Azithromycin Economics Helicobacter Infections Drug Therapy Helicobacter Pylori Drug Effects Patient Compliance Peptic Ulcer Drug Therapy Adult Aged Aged, 80 and Over Amoxicillin Administration and Dosage Brazil Drug Administration Schedule Health Care Costs Drug Therapy, Combination Duodenal Ulcer Drug Therapy Duodenal Ulcer Microbiology Female Helicobacter Infections Microbiology Male Middle Age Omeprazole Administration and Dosage Peptic Ulcer Microbiology Treatment Outcomes Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Background: The Brazilian consensus recommends a short-term treatment course with clarithromycin, amoxicillin and proton-pump inhibitor for the eradication of Helicobacter pylori (H. pylori). This treatment course has good efficacy, but cannot be afforded by a large part of the population. Azithromycin, amoxicillin and omeprazole are subsidized, for several aims, by the Brazilian federal government. Therefore, a short-term treatment course that uses these drugs is a low-cost one, but its efficacy regarding the bacterium eradication is yet to be demonstrated. The study's purpose was to verify the efficacy of H. pylori eradication in infected patients who presented peptic ulcer disease, using the association of azithromycin, amoxicillin and omeprazole.Methods: Sixty patients with peptic ulcer diagnosed by upper digestive endoscopy and H. pylori infection documented by rapid urease test, histological analysis and urea breath test were treated for six days with a combination of azithromycin 500 mg and omeprazole 20 mg, in a single daily dose, associated with amoxicillin 500 mg 3 times a day. The eradication control was carried out 12 weeks after the treatment by means of the same diagnostic tests. The eradication rates were calculated with 95% confidence interval.Results: The eradication rate was 38% per intention to treat and 41% per protocol. Few adverse effects were observed and treatment compliance was high.Conclusion: Despite its low cost and high compliance, the low eradication rate does not allow the recommendation of the triple therapy with azithromycin as an adequate treatment for H. pylori infection. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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