Early afterdepolarisations and ventricular arrhythmias in cardiac tissue: a computational study.
Afterdepolarisations are associated with arrhythmias in the heart, but are difficult to study experimentally. In this study we used a simplified computational model of 1D and 2D cardiac ventricular tissue, where we could control the size of the region generating afterdepolarisations, as well as the...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 47; no. 3; pp. 291 - 301 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105219811&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105219811 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Mar2009 vid: 47 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105219811 NLM18850126 2010207056 10.1007/s11517-008-0405-0 NLM18850126 105219811 ppf: 291 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Early afterdepolarisations and ventricular arrhythmias in cardiac tissue: a computational study. aug: au: Scarle S Clayton RH Scarle, Simon Clayton, Richard H affil: Department of Computer Science, University of Sheffield, Regent Court, 211 Portobello Street, Sheffield S14DP, UK sug: subj: Arrhythmia Physiopathology Heart Conduction System Physiopathology Models, Biological Action Potentials Physiology Bioinformatics Methods Human Premature Ventricular Contractions Physiopathology ab: Afterdepolarisations are associated with arrhythmias in the heart, but are difficult to study experimentally. In this study we used a simplified computational model of 1D and 2D cardiac ventricular tissue, where we could control the size of the region generating afterdepolarisations, as well as the properties of the afterdepolarisation waveform. Provided the size of the afterdepolarisation region was greater than around 1 mm, propagating extrasystoles were produced in both 1D and 2D. The number of extrasystoles produced depended on the amplitude, period, and duration of the oscillatory EAD waveform. In 2D, re-entry was also initiated for specific combinations of EAD amplitude, period, and duration, with the afterdepolarisation region acting as a common pathway. The main finding from this modelling study is therefore that afterdepolarisations can act as potent sources of propagating extrasystoles, as well as a source of re-entrant activation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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