Multi-objective blood glucose control for type 1 diabetes.
For people with type 1 diabetes, automatic controllers aim to maintain the blood glucose concentration within the desired range of 60-120 mg/dL by infusing the appropriate amount of insulin in the presence of meal and exercise disturbances. Blood glucose concentration outside the desired range can b...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 47; no. 3; pp. 343 - 353 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105219821&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105219821 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Mar2009 vid: 47 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105219821 NLM19214613 2010207067 10.1007/s11517-009-0453-0 NLM19214613 105219821 ppf: 343 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Multi-objective blood glucose control for type 1 diabetes. aug: au: Dua P Doyle FJ 3rd Pistikopoulos EN Dua, Pinky Doyle, Francis J 3rd Pistikopoulos, Efstratios N affil: Department of Chemical Engineering, Centre for Process Systems Engineering, Imperial College London, South Kensington Campus, London SW72AZ, UK sug: subj: Blood Glucose Metabolism Diabetes Mellitus, Type 1 Blood Models, Biological Diabetes Mellitus, Type 1 Drug Therapy Drug Administration Schedule Drug Delivery Systems Human Hyperglycemia Prevention and Control Hypoglycemia Prevention and Control Hypoglycemic Agents Administration and Dosage Insulin Administration and Dosage ab: For people with type 1 diabetes, automatic controllers aim to maintain the blood glucose concentration within the desired range of 60-120 mg/dL by infusing the appropriate amount of insulin in the presence of meal and exercise disturbances. Blood glucose concentration outside the desired range can be harmful to an individual's health but concentration below 60 mg/dL, a state known as hypoglycemia, is considered to be more harmful than the concentration above 120 mg/dL, a state known as hyperglycemia. In this paper, two techniques to address this issue within a multi-parametric model based control framework are presented. The first technique introduces asymmetry into the objective function to penalize the deviation towards hypoglycemia more than the deviation towards hyperglycemia. The second technique is based upon placing higher priority on satisfaction of constraints on hypoglycemia than on satisfaction of constraints on hyperglycemia. The performance of both the control techniques is analyzed and compared in the presence of disturbances. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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