A comparison of six software packages for evaluation of solid lung nodules using semi-automated volumetry: what is the minimum increase in size to detect growth in repeated CT examinations.

We compared interexamination variability of CT lung nodule volumetry with six currently available semi-automated software packages to determine the minimum change needed to detect the growth of solid lung nodules. We had ethics committee approval. To simulate a follow-up examination with zero growth...

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Publicado en:European Radiology Vol. 19; no. 4; pp. 800 - 809
Autores principales: de Hoop B, Gietema H, van Ginneken B, Zanen P, Groenewegen G, Prokop M, de Hoop, Bartjan, Gietema, Hester, van Ginneken, Bram, Zanen, Pieter, Groenewegen, Gerard, Prokop, Mathias
Formato: research Journal Article
Publicado: Springer Nature Apr2009
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        atl: A comparison of six software packages for evaluation of solid lung nodules using semi-automated volumetry: what is the minimum increase in size to detect growth in repeated CT examinations.
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          de Hoop B
          Gietema H
          van Ginneken B
          Zanen P
          Groenewegen G
          Prokop M
          de Hoop, Bartjan
          Gietema, Hester
          van Ginneken, Bram
          Zanen, Pieter
          Groenewegen, Gerard
          Prokop, Mathias
        affil: Department of Radiology, University Medical Center, Utrecht, The Netherlands
      sug:
        subj:
          Image Processing, Computer Assisted Methods
          Lung Neoplasms Diagnosis
          Medical Informatics
          Tomography, X-Ray Computed Methods
          Adult
          Aged
          Aged, 80 and Over
          Bar Coding
          Automation
          Female
          Human
          Lung Neoplasms Radiography
          Male
          Middle Age
          Reproducibility of Results
          Software
          Adult: 19-44 years
          Aged: 65+ years
          Aged, 80 & over
          Middle Aged: 45-64 years
          Female
          Male
      ab: We compared interexamination variability of CT lung nodule volumetry with six currently available semi-automated software packages to determine the minimum change needed to detect the growth of solid lung nodules. We had ethics committee approval. To simulate a follow-up examination with zero growth, we performed two low-dose unenhanced CT scans in 20 patients referred for pulmonary metastases. Between examinations, patients got off and on the table. Volumes of all pulmonary nodules were determined on both examinations using six nodule evaluation software packages. Variability (upper limit of the 95% confidence interval of the Bland-Altman plot) was calculated for nodules for which segmentation was visually rated as adequate. We evaluated 214 nodules (mean diameter 10.9 mm, range 3.3 mm-30.0 mm). Software packages provided adequate segmentation in 71% to 86% of nodules (p < 0.001). In case of adequate segmentation, variability in volumetry between scans ranged from 16.4% to 22.3% for the various software packages. Variability with five to six software packages was significantly less for nodules >or=8 mm in diameter (range 12.9%-17.1%) than for nodules <8 mm (range 18.5%-25.6%). Segmented volumes of each package were compared to each of the other packages. Systematic volume differences were detected in 11/15 comparisons. This hampers comparison of nodule volumes between software packages.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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