Activation of liver tryptophan pyrrolase mediates the decrease in tryptophan availability to the brain after acute alcohol consumption by normal subjects.

Aims: We have previously suggested that acute ethanol consumption by normal subjects decreases the availability of circulating tryptophan (Trp) to the brain by activating liver Trp pyrrolase, the first and rate-limiting enzyme of the (major) kynurenine pathway of Trp degradation. The aim of the pres...

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Publicado en:Alcohol & Alcoholism Vol. 44; no. 3; pp. 267 - 272
Autores principales: Badawy AA, Doughrty DM, Marsh-Richard DM, Steptoe A
Formato: Journal Article
Publicado: Oxford University Press / USA May/Jun2009
Acceso en línea:Ver este registro en EBSCOhost