Association of immunoglobulin-like transcript 6 deficiency with Sjögren's syndrome.
OBJECTIVE: The immunoglobulin-like transcript (ILT) family is located in chromosomal region 19q13 and consists of a group of activating and inhibitory receptors. The ILT receptors are expressed on antigen-presenting cells (macrophages, dendritic cells, B lymphocytes), as well as on T cells and natur...
| Publicado en: | Arthritis & Rheumatism Vol. 60; no. 10; pp. 2923 - 2926 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105230602&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105230602 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00043591 04N jtl: Arthritis & Rheumatism issn: 00043591 maglogo: Y pubinfo: dt: Oct2009 vid: 60 iid: 10 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105230602 105230602 2010439604 10.1002/art.24804 NLM19790059 105230602 ppf: 2923 ppct: 3 formats: tig: atl: Association of immunoglobulin-like transcript 6 deficiency with Sjögren's syndrome. aug: au: Kabalak G Dobberstein SB Matthias T Reuter S The YH Dörner T Schmidt RE Witte T affil: Hannover Medical School, Hannover, Germany. sug: subj: Disease Susceptibility Receptors, Cell Surface Sjogren's Syndrome Case Control Studies Female Mutation Human Male Middle Age Receptors, Cell Surface Metabolism Risk Factors Sjogren's Syndrome Metabolism Middle Aged: 45-64 years Female Male ab: OBJECTIVE: The immunoglobulin-like transcript (ILT) family is located in chromosomal region 19q13 and consists of a group of activating and inhibitory receptors. The ILT receptors are expressed on antigen-presenting cells (macrophages, dendritic cells, B lymphocytes), as well as on T cells and natural killer cells. ILT2 and ILT4 play a role in tolerance induction, and ILT3 has been shown to induce Treg cells. A homozygous deletion of ILT6 has been shown to be associated with multiple sclerosis. Since ILT6 may be a modulator of the immune system, we undertook this study to examine the association of ILT6 deficiency with Sjögren's syndrome (SS). METHODS: We genotyped 149 patients with SS and 749 healthy controls, using polymerase chain reaction to test for the presence or absence of ILT6. RESULTS: Homozygous ILT6 deficiency was detected in 8% of SS patients and in only 3% of controls. CONCLUSION: Our findings indicate that ILT6 deficiency may be a genetic risk factor for SS. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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