Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study.
Background: The ability to reduce inflammation in overweight and obese individuals may be valuable in preventing the progression to metabolic syndrome with associated risks for heart disease and diabetes. The purpose of this study was to evaluate the effect of multiple dosages of a proprietary Mango...
| Publicado en: | Nutrition Journal Vol. 8; pp. 48 - 49 |
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| Autores principales: | , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105235674&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105235674 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14752891 1CYY jtl: Nutrition Journal issn: 14752891 maglogo: N pubinfo: dt: 2009 vid: 8 pid: 24147 pub: BioMed Central artinfo: ui: 105235674 NLM19843321 2010456456 10.1186/1475-2891-8-48 NLM19843321 PMC2770545 105235674 ppf: 48 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study. aug: au: Udani JK Singh BB Barrett ML Singh VJ Udani, Jay K Singh, Betsy B Barrett, Marilyn L Singh, Vijay J affil: Medicus Research LLC, Northridge, CA 91325, USA sug: subj: Beverages Adverse Effects Fruit Adverse Effects Plants Adverse Effects Inflammation Prevention and Control Inflammation Mediators Blood Obesity Blood Adipose Tissue Adult Aged Body Mass Index C-Reactive Protein Analysis Double-Blind Studies Arachidonic Acids Blood Female Human Male Middle Age Medicine, Herbal Adverse Effects Pilot Studies Time Factors Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: The ability to reduce inflammation in overweight and obese individuals may be valuable in preventing the progression to metabolic syndrome with associated risks for heart disease and diabetes. The purpose of this study was to evaluate the effect of multiple dosages of a proprietary Mangosteen Juice blend on indicators of inflammation and antioxidant levels in obese patients with elevated C-reactive protein (CRP) levels.Methods: The study was an 8 week randomized, double-blind, placebo-controlled study with a pre-study 2 week washout period. The study included four groups including placebo and three difference doses of the test product, XanGo Juice: 3, 6 or 9 oz twice daily. The primary outcome measure of this study was high-sensitivity (HS)-CRP. Secondary outcome measures included other biochemical indicators of inflammation, anthropomorphic measures and a safety evaluation.Results: One hundred twenty two (122) persons were screened for the study, 44 were randomized and 40 completed the study. HS-CRP measurements dropped after 8 weeks treatment compared to baseline in all 3 dose groups and increased in the placebo group. The changes from baseline were not significant but the comparison of change from baseline was significant for the 18 oz group when compared to placebo (p = 0.02). Other markers of inflammation (inflammatory cytokines) and a marker for lipid peroxidation (F2 isoprostane) did not show any significant differences when compared with placebo. There was a trend towards a decrease in BMI in the juice groups. There were no side effects reported in any of the groups and none of the laboratory or EKG safety assessments indicated clinically significant changes for any subject.Conclusion: In this pilot, dose-finding study, a proprietary mangosteen juice blend (XanGo Juice) reduced CRP levels (increased change from baseline) compared to placebo for those taking the highest dose of 18 oz per day. Further studies with a larger population are required to confirm and further define the benefits of this juice. The juice was administered safely.Trial Registration: ISRCTN9300027. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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