Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for Helicobacter pylori eradication in dyspepsia.
BACKGROUND/AIM: Helicobacter pylori (H pylori) plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease, and gastric neoplasms . Therefore, it is necessary to select an effective regimen for H pylori eradication . The aim of this study was to compare the efficacy of two...
| Publicado en: | Saudi Journal of Gastroenterology Vol. 15; no. 4; pp. 225 - 229 |
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| Autores principales: | , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Oct2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105235771&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105235771 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13193767 322P jtl: Saudi Journal of Gastroenterology issn: 13193767 maglogo: N pubinfo: dt: Oct2009 vid: 15 iid: 4 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 105235771 2010456818 10.4103/1319-3767.56091 NLM19794266 105235771 ppf: 225 ppct: 4 formats: tig: atl: Comparison of azithromycin and metronidazole in a quadruple-therapy regimen for Helicobacter pylori eradication in dyspepsia. aug: au: Agah S Shazad B Abbaszadeh B affil: Departments of Liver and Gastrointestinal Research, Infectious Disease Research, Iran University of Medical Sciences, Tehran, Iran. sug: subj: Azithromycin Administration and Dosage Comparative Studies Dyspepsia Drug Therapy Helicobacter Infections Drug Therapy Metronidazole Administration and Dosage Adult Chi Square Test Clinical Trials Data Analysis Software Double-Blind Studies Helicobacter Infections Complications Helicobacter Pylori Iran Mann-Whitney U Test Middle Age Random Assignment Adult: 19-44 years Middle Aged: 45-64 years ab: BACKGROUND/AIM: Helicobacter pylori (H pylori) plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease, and gastric neoplasms . Therefore, it is necessary to select an effective regimen for H pylori eradication . The aim of this study was to compare the efficacy of two quadruple-therapy regimens-one with azithromycin and the other with metronidazole-for H pylori eradication in patients with dyspepsia. MATERIALS AND METHODS: In this double-blind randomized clinical trial conducted in Rasoule-Akram Hospital in 2006, we included 60 patients (aged 15-70 years) who had dyspepsia and H pylori infection as diagnosed by upper gastrointestinal endoscopy and rapid urease test. Patients were randomly assigned to receive a quadruple-therapy regimen for 2 weeks: 1) the MAO-B group (n = 30) received metronidazole 500 mg b.i.d, amoxicillin 1g b.i.d, omeprazole 20 mg b.i.d, and bismuth 240 mg b.i.d and 2) the AAO-B group (n = 30) received azithromycin 500 mg once daily for 1 week and amoxicillin 1g b.i.d, omeprazole 20 mg b.i.d, and bismuth 240 mg b.i.d for 2 weeks). H pylori eradication was assessed by the rapid urease test (RUT) 2 months after the cessation of treatment . RESULTS: H pylori was eradicated in 68% and 69% of patients in the MAO-B and AAO-B groups, respectively. There was no significant difference in H pylori eradication rates between the two groups (P = 0.939). CONCLUSION: No significant difference exists between the two quadruple-therapy regimens that were tested. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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