Repeatability of nerve conduction measurements derived entirely by computer methods.
Background: Nerve conduction studies are an objective, quantitative, and reproducible measure of peripheral nerve function and are widely used in the diagnosis of neuropathies. The purpose of this study is to determine the reliability of nerve conduction parameters derived entirely from computer bas...
| Publicado en: | BioMedical Engineering OnLine Vol. 8; pp. 33 - 34 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2009
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105247723&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105247723 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1475925X 1CGX jtl: BioMedical Engineering OnLine issn: 1475925X maglogo: N pubinfo: dt: 2009 vid: 8 pid: 24147 pub: BioMed Central artinfo: ui: 105247723 NLM19895683 2010484276 10.1186/1475-925X-8-33 NLM19895683 PMC2777171 105247723 ppf: 33 ppct: 1 formats: tig: atl: Repeatability of nerve conduction measurements derived entirely by computer methods. aug: au: Kong X Lesser EA Gozani SN Kong, Xuan Lesser, Eugene A Gozani, Shai N affil: NeuroMetrix, Inc 62 Fourth Avenue, Waltham, MA, USA sug: subj: Electrodiagnosis Methods Neural Conduction Physiology Adult Aged Algorithms Electrophysiology Female Human Male Middle Age Peripheral Nerves Physiopathology Polyneuritis Diagnosis Polyneuritis Physiopathology Probability Reproducibility of Results Software Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: Nerve conduction studies are an objective, quantitative, and reproducible measure of peripheral nerve function and are widely used in the diagnosis of neuropathies. The purpose of this study is to determine the reliability of nerve conduction parameters derived entirely from computer based data acquisition and waveform cursor assignments and to quantify the relative contributions of test variability sources.Methods: Thirty volunteers, some with symptoms suggestive of neuropathies; of these, 29 completed the study. The median, ulnar, deep peroneal, posterior tibial, and sural nerves were evaluated bilaterally at two test sessions 3-7 days apart. Within each session, nerves were tested twice within 10 minutes. The analyzed nerve conduction parameters include motor latencies, motor conduction velocity (CV), compound muscle action potential (CMAP) amplitude, F-wave latencies (minimum, mean and maximum), sensory peak latency (DSL), sensory CV, and sensory nerve action potential (SNAP) amplitude. The primary outcome measure is variance component analysis and the corresponding coefficient of variation (CoV). The between-session-test variance is the sum of within-session variance and between-session variance, quantifying the total variation between test sessions. Additional statistical measures include the intraclass correlation coefficient (ICC) and relative interval variation (RIV).Results: Motor and sensory latencies, CV and F-wave latency parameters have low between-session-test CoVs, ranging from 4.2% to 9.8%. Amplitude parameters have a higher between-session-test CoVs in the range of 15.6--19.8%. Between-test CoVs are about 30--80% lower than between-session CoVs with the exception of F-wave latency parameters. Between-test ICC values are 0.96 or above for all parameters. Between-session ICC ranges from 0.98 for F-wave latency to 0.77 for sural sensory CV. All latency-related between-session ICCs have a value 0.83 or above. The RIVs are the tightest for F-wave latency parameters and widest for CMAP amplitude parameters. Repeatability in a sub-group of subjects with more severe symptom grades follows the same trend as the overall study population without substantial quantitative differences.Conclusion: The study demonstrates the high repeatability of nerve conduction parameters acquired by modern electrodiagnostic instruments using computer based waveform cursor assignment. The reliability is comparable to benchmark studies in which the nerve conduction measurements were performed manually in controlled multi-center clinical trials. Furthermore, the ranking of reliability, whereby F-wave latencies have the best reproducibility and amplitudes the worst, is also consistent with the benchmark studies. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|