Collecting 48,000 CT exams for the lung screening study of the National Lung Screening Trial.
From 2002-2004, the Lung Screening Study (LSS) of the National Lung Screening Trial (NLST) enrolled 34,614 participants, aged 55-74 years, at increased risk for lung cancer due to heavy cigarette smoking. Participants, randomized to standard chest X-ray (CXR) or computed tomography (CT) arms at ten...
| Publicado en: | Journal of Digital Imaging Vol. 22; no. 6; pp. 667 - 681 |
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| Autores principales: | , , , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105253971&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105253971 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08971889 DOQ jtl: Journal of Digital Imaging issn: 08971889 maglogo: N pubinfo: dt: Dec2009 vid: 22 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105253971 2010491343 10.1007/s10278-008-9145-9 NLM18777192 105253971 ppf: 667 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Collecting 48,000 CT exams for the lung screening study of the National Lung Screening Trial. aug: au: Clark KW Gierada DS Marquez G Moore SM Maffitt DR Moulton JD Wolfsberger MA Koppel P Phillips SR Prior FW affil: Mallinckrodt Institute of Radiology, Washington University, 510 South Kingshighway, Saint Louis, MO 63110, USA. clarkk@mir.wustl.edu sug: subj: Cancer Screening Image Retrieval Image Retrieval Systems Lung Neoplasms Diagnosis Aged Archives Clinical Trials Data Collection Methods Funding Source Human Middle Age Picture Archiving and Communication Systems Radiography, Thoracic Tomography, X-Ray Computed Aged: 65+ years Middle Aged: 45-64 years ab: From 2002-2004, the Lung Screening Study (LSS) of the National Lung Screening Trial (NLST) enrolled 34,614 participants, aged 55-74 years, at increased risk for lung cancer due to heavy cigarette smoking. Participants, randomized to standard chest X-ray (CXR) or computed tomography (CT) arms at ten screening centers, received up to three imaging screens for lung cancer at annual intervals. Participant medical histories and radiologist-interpreted screening results were transmitted to the LSS coordinating center, while all images were retained at local screening centers. From 2005-2007, all CT exams were uniformly de-identified and delivered to a central repository, the CT Image Library (CTIL), on external hard drives (94%) or CD/DVD (5.9%), or over a secure Internet connection (0.1%). Of 48,723 CT screens performed, only 176 (0.3%) were unavailable (lost, corrupted, compressed) while 48,547 (99.7%) were delivered to the CTIL. Described here is the experience organizing, implementing, and adapting the clinical-trial workflow surrounding the image retrieval, de-identification, delivery, and archiving of available LSS-NLST CT exams for the CTIL, together with the quality assurance procedures associated with those collection tasks. This collection of CT exams, obtained in a specific, well-defined participant population under a common protocol at evenly spaced intervals, and its attending demographic and clinical information, are now available to lung-disease investigators and developers of computer-aided-diagnosis algorithms. The approach to large scale, multi-center trial CT image collection detailed here may serve as a useful model, while the experience reported should be valuable in the planning and execution of future equivalent endeavors. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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