The long-term effects of neonatal seizures.
The highest incidence of seizures occurs during the first hours to days after birth. The immature brain is prone to seizures because of reduced inhibition. GABA, which is the primary inhibitory neurotransmitter in the mature brain, is depolarizing and excitatory in the immature brain. Seizures are a...
| Publicado en: | Clinics in Perinatology Vol. 36; no. 4; pp. 901 - 915 |
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| Autor principal: | |
| Formato: | research Journal Article |
| Publicado: |
W B Saunders
2009 Dec
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105255220&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105255220 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00955108 47E jtl: Clinics in Perinatology issn: 00955108 maglogo: N pubinfo: dt: 2009 Dec vid: 36 iid: 4 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 105255220 105255220 2010492742 10.1016/j.clp.2009.07.012 NLM19944841 105255220 ppf: 901 ppct: 14 formats: tig: atl: The long-term effects of neonatal seizures. aug: au: Holmes GL affil: Department of Neurology, Dartmouth-Hitchcock Medical Center, Neuroscience Center at Dartmouth, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA. sug: subj: Brain Metabolism Cognition Seizures Diagnosis Seizures Metabolism Seizures Physiopathology Animals Brain Physiopathology Disease Progression Electroencephalography Prospective Studies Human Infant, Newborn Time Factors Infant, Newborn: birth-1 month ab: The highest incidence of seizures occurs during the first hours to days after birth. The immature brain is prone to seizures because of reduced inhibition. GABA, which is the primary inhibitory neurotransmitter in the mature brain, is depolarizing and excitatory in the immature brain. Seizures are an ominous sign, indicating either an acquired brain insult or a genetic abnormality. While the primary outcome determinant of neonatal seizures is etiology, whether seizures can result in long-term adverse consequences independently is not clear. While the clinical data is uncertain, there is now a considerable body of evidence indicating that in animals, neonatal seizures can adversely alter the developing brain. Animal data indicates that the sequelae of seizures are strongly age dependent; seizures will affect the developing and plastic neuronal circuitry much differently than the fixed circuitry of the mature brain. Seizures at an early developmental stage can dramatically affect the construction of networks, resulting in severe and permanent handicaps in some patients. In the young brain, the long-lasting detrimental consequences of seizures are caused by an alteration of developmental programs rather than by neuronal cell loss, as occurs in adults. In animal models, neonatal seizures result in decreases in neurogenesis, sprouting of mossy fibers, and long-standing changes in signaling properties. Seizures in rat pups are also associated with abnormalities in firing patterns of single cells in the hippocampus. Furthermore, these anatomic and physiologic changes correlate well with behavioral dysfunction.Copyright © 2009 by Elsevier Inc. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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