Left versus right atrial difference in dominant frequency, K(+) channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery.
Background: The development of atrial fibrillation (AF) after cardiac surgery is associated with adverse outcomes; however, the mechanism(s) that trigger and maintain AF in these patients are unknown.Objective: The purpose of this study was to test our hypothesis that postoperative AF is maintained...
| Publicado en: | Heart Rhythm Vol. 6; no. 10; pp. 1415 - 1423 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Oct2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105260783&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105260783 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15475271 EHI jtl: Heart Rhythm issn: 15475271 maglogo: N pubinfo: dt: Oct2009 vid: 6 iid: 10 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 105260783 105260783 NLM19656731 2010499936 10.1016/j.hrthm.2009.06.018 NLM19656731 PMC2790556 105260783 ppf: 1415 ppct: 8 formats: tig: atl: Left versus right atrial difference in dominant frequency, K(+) channel transcripts, and fibrosis in patients developing atrial fibrillation after cardiac surgery. aug: au: Swartz MF Fink GW Lutz CJ Taffet SM Berenfeld O Vikstrom KL Kasprowicz K Bhatta L Puskas F Kalifa J Jalife J Swartz, Michael F Fink, Gregory W Lutz, Charles J Taffet, Steven M Berenfeld, Omer Vikstrom, Karen L Kasprowicz, Kimberly Bhatta, Luna Puskas, Ferenc affil: Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY, USA sug: subj: Atrial Fibrillation Physiopathology Cardiac Surgery Fibrosis Pathology Heart Atrium Pathology Potassium Analysis Aged Electrocardiography Female Mathematics Heart Atrium Physiopathology Human Nerve Tissue Proteins Analysis Male Middle Age Postoperative Complications Reverse Transcriptase Polymerase Chain Reaction Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: The development of atrial fibrillation (AF) after cardiac surgery is associated with adverse outcomes; however, the mechanism(s) that trigger and maintain AF in these patients are unknown.Objective: The purpose of this study was to test our hypothesis that postoperative AF is maintained by high-frequency sources in the left atrium (LA) resulting from ion channel and structural features that differ from the right atrium (RA).Methods: Forty-four patients with no previous history of AF who underwent cardiac surgery consented to LA and RA biopsies. Histologic sections evaluated fatty infiltration, fibrosis, and iron deposition; quantitative reverse transcription-polymerase chain reaction (RT-PCR) assessed ion channel expression. In a subset of 27 patients, LA and RA unipolar recording leads were also placed. In patients who developed AF, the dominant frequency (DF) for each lead was calculated using fast Fourier transform.Results: DFs during AF were LA 6.26 +/- 0.8 Hz, RA 4.56 +/- 0.7 Hz (P <.01). RT-PCR revealed LA-to-RA differences in mRNA abundance for Kir2.3 (1.8:1) and Kir3.4 (2.3:1). While LA fibrosis was greater in patients developing AF compared with those remaining in normal sinus rhythm (10.8% +/- 11% vs. 3.8% +/- 3.5%; P = .03), the amount of LA fibrosis inversely correlated with the LA DF.Conclusions: This is the first demonstration of LA-to-RA frequency differences during postoperative AF, which are associated with LA-to-RA differences in mRNA levels for potassium channel proteins and LA fibrosis. These results strongly suggest that sources of AF after cardiac surgery are located in the LA and are stabilized by LA fibrosis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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