Invited commentary: Evaluating vaccination programs using genetic sequence data.
Genomic data will become an increasingly important component of epidemiologic studies in coming years. The authors of the accompanying Journal article, van Ballegooijen et al. (Am J Epidemiol. 2009;170(12):1455-1463), are to be commended for attempting to use the coalescent analysis of viral sequenc...
| Publicado en: | American Journal of Epidemiology Vol. 170; no. 12; pp. 1464 - 1467 |
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| Autores principales: | , |
| Formato: | commentary Journal Article |
| Publicado: |
Oxford University Press / USA
Dec2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105267822&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105267822 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029262 1X1 jtl: American Journal of Epidemiology issn: 00029262 maglogo: N pubinfo: dt: Dec2009 vid: 170 iid: 12 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105267822 2010508883 10.1093/aje/kwp366 NLM19910381 PMC2800275 105267822 ppf: 1464 ppct: 3 formats: tig: atl: Invited commentary: Evaluating vaccination programs using genetic sequence data. aug: au: Halloran ME Holmes EC affil: Statistics and Quantitative Infectious Diseases, Seattle, WA 98109, USA. betz@u.washington.edu sug: subj: Genomics Utilization Immunization Sequence Analysis Utilization Treatment Outcomes Confounding Variable Database Quality Disease Surveillance Methods Hepatitis B Population Surveillance Methods Sampling Methods Theory ab: Genomic data will become an increasingly important component of epidemiologic studies in coming years. The authors of the accompanying Journal article, van Ballegooijen et al. (Am J Epidemiol. 2009;170(12):1455-1463), are to be commended for attempting to use the coalescent analysis of viral sequence data to evaluate a hepatitis B vaccination program. Coalescent theory attempts to link the phylogenetic history of populations with rates of population growth and decline. In particular, under certain assumptions, a reduction in genetic diversity can be interpreted as a reduction in disease incidence. However, the authors of this commentary contend that van Ballegooijen et al.'s interpretation of changes in viral genetic diversity as a measure of hepatitis B vaccine effectiveness has major limitations. Because of the potential use of these methods in future vaccination studies, the authors discuss the utility of these methods and the data requirements needed for them to be convincing. First, data sets should be large enough to provide sufficient epidemiologic-scale resolution. Second, data need to reflect sufficiently fine-grained temporal sampling. Third, other processes that can potentially influence genetic diversity and confuse demographic inferences should be considered. pubtype: Academic Journal doctype: commentary Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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