Helicobacter pylori and gastroduodenal ulcer disease.
Background: Helicobacter pylori-associated diseases and gastroduodenal ulcer disease are common conditions of major clinical and economic importance. There is thus a need for a guideline that incorporates the scientific knowledge gained in recent years and that takes specific aspects of the situatio...
| Published in: | Deutsches Ärzteblatt International Vol. 106; no. 49; pp. 801 - 810 |
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| Main Authors: | , , , , , |
| Format: | practice guidelines tables/charts Journal Article |
| Published: |
Deutscher Aerzte-Verlag GmbH
12/4/2009
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105272598&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105272598 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18660452 5F0N jtl: Deutsches Ärzteblatt International issn: 18660452 maglogo: N pubinfo: dt: 12/4/2009 vid: 106 iid: 49 pid: 25312 pub: Deutscher Aerzte-Verlag GmbH artinfo: ui: 105272598 105272598 2010512960 10.3238/arztebl.2009.0801 NLM20038978 PMC2797331 105272598 ppf: 801 ppct: 9 formats: fmt: @attributes: type: T tig: atl: Helicobacter pylori and gastroduodenal ulcer disease. aug: au: Fischbach W Malfertheiner P Hoffmann JC Bolten W Kist M Koletzko S affil: Medizinische Klinik II und Klinik für Palliativmedizin, Klinikum Aschaffenburg sug: subj: Helicobacter Infections Complications Helicobacter Pylori Peptic Ulcer Etiology Helicobacter Infections Diagnosis Helicobacter Infections Drug Therapy Peptic Ulcer Diagnosis Peptic Ulcer Drug Therapy Practice Guidelines ab: Background: Helicobacter pylori-associated diseases and gastroduodenal ulcer disease are common conditions of major clinical and economic importance. There is thus a need for a guideline that incorporates the scientific knowledge gained in recent years and that takes specific aspects of the situation in Germany into account with regard to epidemiology, resistance status, diagnostic evaluation, and treatment. Methods: This level-S3 consensus guideline was developed in accordance with the recommendations of the Association of Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF). It was commissioned by the German Association for Digestive and Metabolic Diseases (Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten, DGVS) and prepared in cooperation with other scientific societies. After search terms were compiled, a systematic, IT-supported literature search was performed in the PubMed and Cochrane databases. The search was restricted to articles that appeared in German or English from 2000 onward. Results: H. pylori infection can be accurately diagnosed either non-invasively (with a 13C-urea breath test or a stool antigen test) or invasively (with a rapid urease test, by histology, or by culture). Gastric and duodenal ulcer and gastric MALT lymphoma are absolute indications for eradication therapy; relative indications include functional dyspepsia, the prevention of gastric cancer in persons at risk, the initiation of long-term treatment with non-steroidal anti-inflammatory drugs (NSAID), and the prior occurrence of gastroduodenal complications with the use of either NSAID or acetylsalicylic acid (ASA). First-line therapy consists of a proton-pump inhibitor (PPI) and clarithromycin combined with either metronidazole or amoxicillin, given for at least one week. Conclusion: This guideline enables the structured, evidence-based diagnosis and treatment of H. pylori infection and associated conditions, as well as of gastroduodenal ulcer disease. pubtype: Academic Journal doctype: practice guidelines tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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