Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm.
Objective: To estimate population pharmacokinetic parameters of repaglinide in 121 healthy Malaysian volunteers. Methods: Each subject received 4 mg of oral repaglinide. Six blood samples were taken per individual (0, 30, 60, 120, 180 and 240 min) for repaglinide's serum concentration determination...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 35; no. 1; pp. 105 - 113 |
|---|---|
| Autores principales: | , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2010
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105281553&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105281553 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Feb2010 vid: 35 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 105281553 2010523725 10.1111/j.1365-2710.2009.01042.x NLM20175819 105281553 ppf: 105 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm. aug: au: Ruzilawati AB Suhaimi AWM Gan SH affil: Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; tieimran@yahoo.com sug: subj: Repaglinide Blood Repaglinide Pharmacokinetics Adult Chromatography, High Pressure Liquid Data Analysis Software Descriptive Statistics Funding Source Human Malaysia Middle Age Adult: 19-44 years Middle Aged: 45-64 years ab: Objective: To estimate population pharmacokinetic parameters of repaglinide in 121 healthy Malaysian volunteers. Methods: Each subject received 4 mg of oral repaglinide. Six blood samples were taken per individual (0, 30, 60, 120, 180 and 240 min) for repaglinide's serum concentration determination by using high-performance liquid chromatography. The parametric Iterative Two-Stage Bayesian Population Model ( it2b ) program followed by the Non-Parametric Adaptive Grid ( npag ) program was used to determine a population pharmacokinetic modelling of repaglinide. Results: Using the npag program, the mean elimination rate constant ( kel) of repaglinide was 0·58 ± 0·27 h and the volume of distribution (Vd) was 23·09 ± 9·19 L/h. Conclusion: In this first report, specifically on the population pharmacokinetic modelling of repaglinide, the data generated should help us to better understand appropriate dosage-regimens for the drug. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|